US 12,350,488 B2
System and method for intermittent electrical modulation
Wouter R Van Furth, Leiden (NL); Nienke R. Biermasz, Leiden (NL); and Amir H. Zamanipoor Najafabadi, Leiden (NL)
Assigned to ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC), Leiden (NL)
Appl. No. 17/293,957
Filed by ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC), Leiden (NL)
PCT Filed Nov. 14, 2019, PCT No. PCT/NL2019/050745
§ 371(c)(1), (2) Date May 14, 2021,
PCT Pub. No. WO2020/101493, PCT Pub. Date May 22, 2020.
Claims priority of application No. 2021998 (NL), filed on Nov. 14, 2018.
Prior Publication US 2022/0001170 A1, Jan. 6, 2022
Int. Cl. A61N 1/05 (2006.01); A61N 1/36 (2006.01); A61N 1/375 (2006.01)
CPC A61N 1/0539 (2013.01) [A61N 1/0534 (2013.01); A61N 1/3606 (2013.01); A61N 1/36071 (2013.01); A61N 1/37518 (2017.08)] 20 Claims
OG exemplary drawing
 
1. A percutaneous system intended to be fixed in an osseous structure of a mammalian patient for intermittent electrical stimulation, the percutaneous system comprising:
an electrode or electrode array comprising one or more electrodes including a distal end configured to be implanted in an organ comprising brain tissue of the patient for intermittent electrical stimulation thereof, wherein the organ comprises a pituitary gland, and
an electric connection means configured to be connected to a proximal end of the electrode or electrode array and configured to be surgically fixed, with a dedicated holder, in an osseous structure of the sphenoid bone, the electric connection means reversibly connected electrically to a source of electrical stimulation for the electrode or electrode array.
 
15. A method for intermittent electrical stimulation, comprising:
implanting a distal end of an electrode or electrode array in an organ comprising brain tissue of a mammalian patient for intermittent electrical stimulation, wherein a proximal end of the electrode or electrode array is provided with a connection plug and the organ comprises a pituitary gland,
attaching the connection plug to the sphenoid bone, wherein the proximal end of the connection plug is reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the electrode or electrode array.