US 12,350,459 B2
Microstructure-based drug injection device and method for manufacturing the same
Jun Ho Jeong, Daejeon (KR); So Hee Jeon, Daejeon (KR); Ki Don Kim, Daejeon (KR); Seok Min Yoon, Daejeon (KR); and Joo Buom Lee, Daejeon (KR)
Assigned to KOREA INSTITUTE OF MACHINERY & MATERIALS, Daejeon (KR)
Appl. No. 17/277,638
Filed by KOREA INSTITUTE OF MACHINERY & MATERIALS, Daejeon (KR); and ADM BIOSCIENCE INC., Daejeon (KR)
PCT Filed Sep. 18, 2019, PCT No. PCT/KR2019/012085
§ 371(c)(1), (2) Date Mar. 18, 2021,
PCT Pub. No. WO2020/060195, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 10-2018-0111529 (KR), filed on Sep. 18, 2018.
Prior Publication US 2022/0023604 A1, Jan. 27, 2022
Int. Cl. A61M 37/00 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); B29C 39/02 (2006.01); B29C 39/22 (2006.01); B29L 31/00 (2006.01)
CPC A61M 37/0015 (2013.01) [A61K 9/0024 (2013.01); A61K 9/0097 (2013.01); A61K 9/16 (2013.01); B29C 39/026 (2013.01); B29C 39/22 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); B29K 2995/006 (2013.01); B29L 2031/7544 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method for manufacturing a microstructure-based drug injection device, comprising:
preparing a forming mold having a shape that corresponds to a microstructure to be manufactured;
applying a biodegradable material-mixed solution to the forming mold;
primary drying at a first temperature to form a needle film where the microstructure is formed by drying the biodegradable material-mixed solution applied to the forming mold;
drug filling for filling a drug in a filling space formed by the microstructure; and
secondary drying at a second temperature less than the first temperature to dry the needle film subsequent to the drug filling,
wherein an inner space is formed in an area other than an area where the drug is accommodated in the filling space that has undergone the secondary drying.