US 12,350,404 B2
3D-porous hybrid anti-inflammatory nanoscaffold for drug delivery and tissue engineering
Ki-Bum Lee, Monmouth Junction, NJ (US); Letao Yang, Edison, NJ (US); and Brian Conley, West Windsor, NJ (US)
Assigned to RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US)
Filed by Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed on May 14, 2020, as Appl. No. 16/874,313.
Application 16/874,313 is a continuation in part of application No. PCT/US2018/061301, filed on Nov. 15, 2018.
Claims priority of provisional application 62/586,468, filed on Nov. 15, 2017.
Prior Publication US 2021/0015975 A1, Jan. 21, 2021
Int. Cl. A61L 27/54 (2006.01); A61K 9/00 (2006.01); A61K 33/32 (2006.01); A61K 38/00 (2006.01); A61K 47/36 (2006.01); A61L 31/14 (2006.01); B82Y 5/00 (2011.01); C12N 5/0793 (2010.01); B82Y 40/00 (2011.01)
CPC A61L 27/54 (2013.01) [A61K 9/0024 (2013.01); A61K 33/32 (2013.01); A61K 38/00 (2013.01); A61K 47/36 (2013.01); A61L 31/148 (2013.01); C12N 5/0619 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A biodegradable scaffolding material comprising a hybrid support structure consisting of manganese dioxide support structures, and at least one of a plurality of extracellular matrix proteins or a plurality of extracellular matrix polysaccharides,
wherein the manganese dioxide support structures consist of two-dimension nanosheets;
wherein the manganese dioxide support structures define a structure comprising a plurality of interstices and
the plurality of extracellular matrix proteins or plurality of extracellular matrix polysaccharides are disposed around and between the manganese dioxide support structures and through the manganese dioxide support structure interstices;
wherein the extracellular matrix proteins or extracellular matrix polysaccharides have a binding affinity with the manganese dioxide support structures, and together form at least one 3-dimensional nanoscaffold, and
wherein either the nanoscaffold thickness, protein concentrations utilized to assemble the two-dimension nanosheets, or both, are selected in combination with the aspect ratio of the nanoscaffold to set the zero-order degradation rate of the nanoscaffold.