	US 12,350,353 B2
	Synthetic enamel and uses thereof
Yuwei Fan, Boston, MA (US); Lina Fahad N. Mengari, Boston, MA (US); and Zhi Sun, Brighton, MA (US)
Assigned to TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US)
Filed by Trustees of Boston University, Boston, MA (US)
Filed on Nov. 16, 2023, as Appl. No. 18/511,294.
Claims priority of provisional application 63/425,842, filed on Nov. 16, 2022.
Prior Publication US 2024/0156696 A1, May 16, 2024
Int. Cl. A61Q 11/00 (2006.01); A61K 8/21 (2006.01); A61K 8/24 (2006.01); A61K 8/27 (2006.01); A61K 8/36 (2006.01); A61K 31/185 (2006.01); A61K 33/06 (2006.01); A61K 33/16 (2006.01); A61K 33/42 (2006.01)

CPC A61K 8/21 (2013.01) [A61K 8/24 (2013.01); A61K 8/36 (2013.01); A61K 31/185 (2013.01); A61K 33/06 (2013.01); A61K 33/16 (2013.01); A61K 33/42 (2013.01); A61Q 11/00 (2013.01); A61K 2800/596 (2013.01); A61K 2800/805 (2013.01); A61K 2800/92 (2013.01)]

22 Claims

1. A remineralization composition comprising:

a. calcium in a concentration from about 0.1 mM to about 500 mM;

b. phosphate in a concentration from about 0.1 mM to about 100 mM; and

c. fluoride in a concentration from about 0.2 ppm to about 300 ppm,

wherein the composition has a pH of from no less than 7.1 to about 8, and an ionic strength of from about 50 mM to about 500 mM, and

wherein the remineralization composition further comprises: (i) strontium in a concentration about 0.05 ppm to about 300 ppm; or (ii) stannous in a concentration from about 0.1 ppm to about 50 ppm.