	US 12,350,341 B2
	Methods for the treatment of cancer and benign lesions by ablation
Robert Morhard, Durham, NC (US); Nirmala Ramanujam, Durham, NC (US); and David Katz, Raleigh, NC (US)
Assigned to Duke University, Durham, NC (US)
Appl. No. 16/490,227
Filed by Duke University, Durham, NC (US)
PCT Filed Mar. 2, 2018, PCT No. PCT/US2018/020589 § 371(c)(1), (2) Date Aug. 30, 2019, PCT Pub. No. WO2018/160926, PCT Pub. Date Sep. 7, 2018.
Claims priority of provisional application 62/465,949, filed on Mar. 2, 2017.
Prior Publication US 2019/0381178 A1, Dec. 19, 2019
Int. Cl. A61K 47/38 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/045 (2006.01); A61K 45/06 (2006.01); A61K 49/00 (2006.01); A61P 17/02 (2006.01); A61P 35/00 (2006.01)

CPC A61K 47/38 (2013.01) [A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 31/045 (2013.01); A61K 45/06 (2013.01); A61K 49/0043 (2013.01); A61P 17/02 (2018.01); A61P 35/00 (2018.01)]

21 Claims

1. A method of treating a cancerous lesion or a precancerous lesion in a subject comprising administering to the subject a therapeutically effective amount of:

a therapy solution, said therapy solution comprising a viscous carrier, wherein said viscous carrier comprises ethyl cellulose, and in which the concentration of ethyl cellulose in the therapy solution is at least 36% by weight; and

an alcohol or hydrophobic agent, such that the lesion is treated,

wherein the therapy solution is administered at a rate of from about 1 mL/hr to about 15 mL/hr.