	US 12,350,322 B2
	Peptide immunogens targeting interleukin 6 (IL-6) and formulations thereof for immunotherapy of diseases impacted by IL-6 dysregulation
Chang Yi Wang, Cold Spring Harbor, NY (US); Feng Lin, Hauppauge, NY (US); Jiun Bo Chen, Taipei (TW); and Shuang Ding, Hauppauge, NY (US)
Assigned to United Biomedical, Inc., Hauppauge, NY (US)
Appl. No. 17/419,163
Filed by UNITED BIOMEDICAL, INC., Hauppauge, NY (US)
PCT Filed Dec. 28, 2019, PCT No. PCT/US2019/068854 § 371(c)(1), (2) Date Jun. 28, 2021, PCT Pub. No. WO2020/140106, PCT Pub. Date Jul. 2, 2020.
Claims priority of provisional application 62/786,192, filed on Dec. 28, 2018.
Prior Publication US 2022/0105163 A1, Apr. 7, 2022
Int. Cl. A61K 39/00 (2006.01); A61K 39/008 (2006.01); A61P 29/00 (2006.01); C07K 16/24 (2006.01)

CPC A61K 39/008 (2013.01) [A61K 39/00114 (2018.08); A61P 29/00 (2018.01); C07K 16/248 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/6031 (2013.01); A61K 2039/627 (2013.01); A61K 2039/804 (2018.08); A61K 2039/884 (2018.08)]

8 Claims

1. An IL-6 peptide immunogen construct represented by the formulae:

(Th)_m-(A)_n-(IL-6R binding region of IL-6 or a fragment thereof)-X

(IL-6R binding region of IL-6 or a fragment thereof)-(A)_n-(Th)_m-X

(Th)_m-(A)_n-(IL-6R binding region of IL-6 or a fragment thereof)-(A)_n-(Th)_m-X

wherein

Th is a heterologous T helper epitope selected from the group consisting of SEQ ID NOs: 89 and 91;

A is a heterologous spacer;

IL-6R binding region of IL-6 or a fragment thereof is selected from the group consisting of SEQ ID NOs: 5 to 19;

X is an α-COOH or α-CONH₂of an amino acid;

m is from 1 to 4; and

n is from 0 to about b 10.