US 12,350,271 B2
Gamma polyglutamated aminopterin and uses thereof
Clet Niyikiza, Gulph Mills, PA (US); and Victor Mandla Moyo, Ringoes, NJ (US)
Assigned to L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
Appl. No. 16/967,533
Filed by L.E.A.F. HOLDINGS GROUP LLC, Gulph Mills, PA (US)
PCT Filed Feb. 7, 2019, PCT No. PCT/US2019/016959
§ 371(c)(1), (2) Date Aug. 5, 2020,
PCT Pub. No. WO2019/160732, PCT Pub. Date Aug. 22, 2019.
Claims priority of provisional application 62/764,945, filed on Aug. 17, 2018.
Claims priority of provisional application 62/702,774, filed on Jul. 24, 2018.
Claims priority of provisional application 62/662,372, filed on Apr. 25, 2018.
Claims priority of provisional application 62/630,751, filed on Feb. 14, 2018.
Prior Publication US 2021/0213019 A1, Jul. 15, 2021
Int. Cl. A61K 31/519 (2006.01); A61K 9/1272 (2025.01); A61K 9/1277 (2025.01); A61K 31/282 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61P 35/04 (2006.01); C07K 16/28 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 9/1272 (2013.01); A61K 9/1277 (2013.01); A61K 31/282 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01); A61P 35/04 (2018.01); C07K 16/2818 (2013.01)] 25 Claims
 
1. A liposomal composition comprising a liposome encapsulating a gamma polyglutamated aminopterin comprising 2-10 glutamyl groups containing gamma carboxyl group linkages, wherein the liposome is pegylated and does not contain a targeting moiety having specific affinity for a surface antigen on a target cell.