US 12,350,147 B2
Adaptable prosthetic tissue valves
Robert G Matheny, Norcross, GA (US)
Assigned to Corvivo Cardiovascular, Inc., Gainesville, FL (US)
Filed by CorMatrix Cardiovascular, Inc., Roswell, GA (US)
Filed on Feb. 22, 2021, as Appl. No. 17/181,161.
Application 17/181,161 is a continuation in part of application No. 16/440,504, filed on Jun. 13, 2019, granted, now 11,160,903.
Application 17/181,161 is a continuation in part of application No. 16/129,968, filed on Sep. 13, 2018, granted, now 10,952,843.
Application 17/181,161 is a continuation in part of application No. 15/206,833, filed on Jul. 11, 2016, granted, now 10,188,510, issued on Jan. 29, 2019.
Application 17/181,161 is a continuation in part of application No. 14/960,354, filed on Dec. 5, 2015, granted, now 9,907,649, issued on Mar. 6, 2018.
Application 17/181,161 is a continuation in part of application No. 14/229,854, filed on Mar. 29, 2014, granted, now 9,308,084, issued on Apr. 12, 2016.
Prior Publication US 2021/0169644 A1, Jun. 10, 2021
Int. Cl. A61F 2/24 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01)
CPC A61F 2/2412 (2013.01) [A61F 2/2418 (2013.01); A61L 27/3625 (2013.01); A61L 27/3629 (2013.01); A61L 27/3633 (2013.01); A61L 27/3641 (2013.01); A61L 27/3826 (2013.01); A61L 27/54 (2013.01); A61F 2230/006 (2013.01); A61F 2230/0067 (2013.01); A61L 2300/402 (2013.01); A61L 2300/406 (2013.01); A61L 2300/408 (2013.01); A61L 2300/41 (2013.01); A61L 2300/416 (2013.01); A61L 2300/42 (2013.01); A61L 2430/20 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An adaptable prosthetic valve for modulating fluid flow through an atrioventricular (AV) valve annulus region during cardiac cycles of a heart, said AV valve annulus region comprising a plurality of AV valve annulus configurations and a plurality of AV valve annulus dimensions, said prosthetic valve comprising:
a base valve member and an internal support structure, said base valve member comprising a continuous sheet member,
said base valve member comprising mammalian-based tissue from a mammalian tissue source,
said base valve member comprising an internal lumen adapted to transmit fluid flow therethrough, a proximal annular engagement end and a distal end,
said proximal annular engagement end being configured to engage said AV valve annulus region,
said proximal annular engagement end being further configured and adapted to transition from a first proximal annular engagement end operative configuration to a second proximal annular engagement end operative configuration, and a first proximal annular engagement end operative dimension and a second proximal annular engagement end operative dimension,
said first proximal annular engagement end operative configuration conforming to a first AV valve annulus region configuration of said plurality of AV valve annulus configurations, said first proximal annular engagement end operative dimension conforming to a first AV valve annulus region dimension of said plurality of AV valve annulus dimensions, said second proximal annular engagement end operative configuration conforming to a second AV valve annulus region configuration of said plurality of AV valve annulus configurations, and said second proximal annular engagement end operative dimension conforming to a second AV valve annulus region dimension of said plurality of AV valve annulus dimensions,
said first proximal annular engagement end operative configuration conforming to said first AV valve annulus region configuration, said first proximal annular engagement end operative dimension conforming to said first AV valve annulus region dimension, said second proximal annular engagement end operative configuration conforming to said second AV valve annulus region configuration, and said second proximal annular engagement end operative dimension conforming to said second AV valve annulus region dimension,
said proximal annular engagement end of the base valve member comprising a plurality of equally spaced ribbon members,
each of said plurality of ribbon members comprising proximal and distal ends, a first edge region extending from said proximal end of each of said plurality of ribbon members to said distal end of each of said plurality of ribbon members and a second edge region extending from said proximal end of each of said plurality of ribbon members to said distal end of each of said plurality of ribbon members,
said plurality of ribbon members being positioned circumferentially about said proximal annular engagement end and extending toward said distal end of said base valve member, wherein said first edge regions of said plurality of ribbon members are positioned proximate said second edge regions of said plurality of ribbon members, wherein a plurality of fluid flow modulating regions is formed between adjacent ribbons of said plurality of ribbon members,
said distal ends of said plurality of ribbon members being disposed proximate each other in a joined relationship, wherein said fluid flow through said distal end of said base valve member is restricted while said fluid flow is allowed to be transmitted through said plurality of fluid flow modulating regions when in an open position,
said base valve member, when said proximal annular engagement end of said base valve member is engaged to said AV valve annulus region, being configured to transition from an expanded position, wherein said base valve member receives said fluid flow therein and said fluid flow exhibits a first fluid flow pressure, to a collapsed position when said fluid flow exhibits a second fluid flow pressure, said second fluid flow pressure being lower than said first fluid flow pressure,
said plurality of fluid flow modulating regions being configured to transition from an open fluid flow position when said base valve member is in said expanded position, wherein said plurality of fluid flow modulating regions allow said fluid flow to be transmitted through said base valve member, to a closed fluid flow position when said base valve member is in said collapsed position, wherein said plurality of fluid flow modulating regions restrict said fluid flow through said base valve member,
said support structure comprising a base and a plurality of elongated support members having proximal and distal ends, said base being disposed proximate said distal end of said base valve member, said support structure comprising support members extending from said base to a ribbon member region distal to the proximal ends of the ribbon members,
a proximal end of said support structure comprising a discontinuous, cross-linked circumferential proximal end,
said plurality of elongated support members being adapted to exert an outwardly projecting retaining force on the proximal annular engagement end, whereby said support structure positions said proximal annular engagement end of said base valve member adjacent to and, thereby, in contact with said AV valve annulus region and induces said transition of said proximal annular engagement end of said base valve member from said first proximal annular engagement end operative configuration to said second proximal annular engagement end operative configuration, and said first proximal annular engagement end operative dimension to said second proximal annular engagement end operative dimension in response to a transition of said first AV valve annulus region configuration to said second AV valve annulus region configuration and said first AV valve annulus region dimension to said second AV valve annulus region dimension, wherein said proximal annular engagement end of said base valve member remains in contact with said AV valve annulus region.