US 12,350,068 B2
Magnetic resonance imaging device and method for precisely measuring cerebral oxygen metabolism
Hyunyeol Lee, Daegu (KR)
Assigned to KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY—ACADEMIC COOPERATION, Daegu (KR)
Appl. No. 18/288,730
Filed by KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION, Daegu (KR)
PCT Filed Apr. 11, 2022, PCT No. PCT/KR2022/005168
§ 371(c)(1), (2) Date Oct. 27, 2023,
PCT Pub. No. WO2022/231167, PCT Pub. Date Nov. 3, 2022.
Claims priority of application No. 10-2021-0055882 (KR), filed on Apr. 29, 2021.
Prior Publication US 2024/0206808 A1, Jun. 27, 2024
Int. Cl. A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/56 (2006.01)
CPC A61B 5/4866 (2013.01) [A61B 5/0042 (2013.01); A61B 5/055 (2013.01); G01R 33/56 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A magnetic resonance imaging device for precisely measuring cerebral oxygen metabolism, the device comprising a memory configured to store computer-readable instructions and one or more processors configured to execute the computer-readable instructions such that the one or more processors are configured to:
acquire UTE (ultrashort echo-time)-AUSFIDE (alternating unbalanced SSFP-FID & SSFP-ECHO) image data, VS-VSL (velocity-selective venous spin labeling) image data, and pCASL (pseudo-continuous arterial spin labeling) image data;
process a plurality of preliminary information data for quantitative model processing, based on the acquired UTE (ultrashort echo-time)-AUSFIDE (alternating unbalanced SSFP-FID & SSFP-ECHO) image data and the acquired VS-VSL (velocity-selective venous spin labeling) image data, and to process CBF (cerebral blood flow) information data based on the acquired pCASL (pseudo-continuous arterial spin labeling) image data;
acquire variable information (Yv) to derive an oxygen extraction fraction (OEF) and a cerebral metabolic rate of oxygen (CMRO2) in order to acquire a 3-dimensional oxygen metabolic rate map of an entire brain using the processed plurality of preliminary information data; and
derive the oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO2) using the acquired variable information and to generate an oxygen metabolic rate map image as a magnetic resonance image, based on the derived oxygen extraction fraction (OEF) and the derived cerebral metabolic rate of oxygen (CMRO2),
wherein the one or more processors are configured to process cerebral blood volume (CBVv) information data among the plurality of preliminary information data, based on the VS-VSL (velocity-selective venous spin labeling) image data.