US 12,350,050 B2
Intraluminal microneurography probes and related systems and methods
Jin Shimada, White Bear Lake, MN (US); Harry Puryear, Shoreview, MN (US); and Gregory Brucker, Minneapolis, MN (US)
Assigned to Recor Medical, Inc., Palo Alto, CA (US)
Filed by RECOR MEDICAL, INC., Palo Alto, CA (US)
Filed on Nov. 4, 2021, as Appl. No. 17/453,636.
Application 17/453,636 is a continuation in part of application No. 16/517,180, filed on Jul. 19, 2019, granted, now 11,642,061.
Application 17/453,636 is a continuation in part of application No. 15/943,354, filed on Apr. 2, 2018, granted, now 11,510,731.
Application 16/517,180 is a continuation of application No. 15/299,694, filed on Oct. 21, 2016, abandoned.
Application 15/299,694 is a continuation of application No. 15/204,349, filed on Jul. 7, 2016, abandoned.
Application 15/943,354 is a continuation of application No. 14/683,966, filed on Apr. 10, 2015, granted, now 9,999,463, issued on Jun. 19, 2018.
Claims priority of provisional application 63/110,920, filed on Nov. 6, 2020.
Claims priority of provisional application 62/198,382, filed on Jul. 29, 2015.
Claims priority of provisional application 61/979,339, filed on Apr. 14, 2014.
Prior Publication US 2022/0095979 A1, Mar. 31, 2022
Int. Cl. A61B 5/294 (2021.01); A61B 5/00 (2006.01); A61B 5/20 (2006.01); A61B 5/24 (2021.01); A61B 5/305 (2021.01); A61B 18/14 (2006.01); A61B 18/18 (2006.01); A61B 18/00 (2006.01); A61B 18/12 (2006.01); A61B 18/16 (2006.01)
CPC A61B 5/24 (2021.01) [A61B 5/201 (2013.01); A61B 5/294 (2021.01); A61B 5/305 (2021.01); A61B 5/4836 (2013.01); A61B 5/725 (2013.01); A61B 18/1492 (2013.01); A61B 18/1815 (2013.01); A61B 2018/00023 (2013.01); A61B 2018/00267 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00511 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00839 (2013.01); A61B 2018/1253 (2013.01); A61B 2018/1407 (2013.01); A61B 2018/162 (2013.01); A61B 2018/1861 (2013.01); A61B 2562/028 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A system for use in analyzing neural activity of nerves that surround a biological lumen, the system comprising:
a probe body configured to be introduced into the biological lumen;
a plurality of electrodes supported by the probe body and electrically isolated from one another;
a stimulator electrically coupled to and configured to deliver electrical stimulation via a first pair of the plurality of electrodes E1 and E2 to evoke neural activity by the nerves that surround the biological lumen;
an amplifier configured to produce a sensed signal indicative of evoked neural activity and/or indicative of intrinsic neural activity by the nerves that surround the biological lumen;
the amplifier including a pair of input terminals, an output terminal, and a ground reference terminal;
wherein a second pair of the plurality of electrodes E3 and E5 is electrically coupled to the pair of input terminals of the amplifier to thereby enable the amplifier to produce the sensed signal;
wherein at least one of the plurality of electrodes included in the second pair of the electrodes is not included in the first pair of the plurality of electrodes; and
wherein a remaining one of the plurality of electrodes E4, which is not included in either the first or the second pairs of the plurality of electrodes, is electrically coupled to the ground reference terminal of the amplifier;
wherein an axial distance between the electrodes E1 and E2 is within a range of 1 cm to 6 cm, inclusive;
an axial distance between the electrodes E2 and E3 is within a range of 1 cm to 10 cm, inclusive, when the electrode E3 is in the deployed position;
an axial distance between the electrodes E3 and E4 is within a range of 0.25 cm to 2.5 cm, inclusive, when the electrode E3 is in the deployed position; and
an axial distance between the electrodes E4 and E5 is within a range of 0.25 cm to 2.5 cm, inclusive.