| CPC A61B 5/14552 (2013.01) [A61B 5/0031 (2013.01); A61B 5/14503 (2013.01); A61B 5/14532 (2013.01)] | 34 Claims |

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1. An analyte monitoring system comprising:
an analyte sensor comprising: (i) a sensor housing, (ii) an analyte indicator on at least a portion of the sensor housing and configured to emit an amount of light indicative of an analyte level in a first medium in proximity to the analyte indicator, (iii) a protective material on at least a portion of the analyte indicator, (iv) a light source in the sensor housing and configured to emit excitation light to the analyte indicator, (v) a reference photodetector in the sensor housing and configured to generate a reference signal indicative of an amount of the excitation light received by the reference photodetector, and (vi) a transceiver interface configured to convey sensor measurements including one or more measurements of the reference signal; and
a transceiver comprising: (i) a sensor interface configured to receive the sensor measurements conveyed by the analyte sensor and (ii) a processor configured to infer information about a condition of the environment surrounding the analyte sensor using at least one or more of the sensor measurements;
wherein the excitation light received by the reference photodetector includes light that was emitted by the light source, passed through the analyte indicator and the protective material, and was reflected by the environment surrounding the analyte sensor;
wherein the environment surrounding the analyte sensor includes one or more of tissue, blood, and clotting.
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