US 12,350,042 B2
Continuous analyte measurement systems and systems and methods for implanting them
Udo Hoss, Castro Valley, CA (US); John Charles Mazza, Long Beach, CA (US); Phu Le, Dublin, CA (US); Christopher A. Thomas, Carmel, CA (US); Geoffrey V. McGarraugh, San Rafael, CA (US); and Gary Alan Hayter, Oakland, CA (US)
Assigned to ABBOTT DIABETES CARE INC., Alameda, CA (US)
Filed by ABBOTT DIABETES CARE INC., Alameda, CA (US)
Filed on Feb. 24, 2022, as Appl. No. 17/680,053.
Application 17/680,053 is a continuation of application No. 17/458,034, filed on Aug. 26, 2021.
Application 17/458,034 is a continuation of application No. 17/092,398, filed on Nov. 9, 2020, abandoned.
Application 17/092,398 is a continuation of application No. 15/789,942, filed on Oct. 20, 2017, granted, now 10,827,954, issued on Nov. 10, 2020.
Application 15/789,942 is a continuation of application No. 12/842,013, filed on Jul. 22, 2010, granted, now 9,795,326, issued on Oct. 24, 2017.
Claims priority of provisional application 61/227,967, filed on Jul. 23, 2009.
Prior Publication US 2022/0175282 A1, Jun. 9, 2022
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/1486 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/14865 (2013.01); A61B 5/6833 (2013.01); A61B 5/7221 (2013.01); A61B 5/002 (2013.01); A61B 2560/0443 (2013.01); A61B 2562/227 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A glucose monitoring system, comprising:
a data processing unit configured to be mounted on a skin surface and comprising:
a processor,
a transmitter, and
one or more memories communicatively coupled with the processor; and
a glucose sensor comprising a proximal portion configured to be electrically coupled to the processor of the data processing unit and a distal portion configured to be inserted through the skin surface and in contact with a bodily fluid, wherein the glucose sensor is configured to generate electrical signals indicative of levels of glucose in the bodily fluid, wherein the distal portion comprises:
a plurality of electrodes comprising a working electrode,
a glucose responsive enzyme layer on the working electrode, and
a first membrane layer on the glucose responsive enzyme layer configured to modulate a flux of glucose to the glucose responsive enzyme layer,
wherein the glucose sensor is configured to provide for perpendicular and lateral diffusion of glucose through the first membrane layer to the glucose responsive enzyme layer, and
wherein a sensor specific calibration parameter for the glucose sensor is stored in the one or more memories, the sensor specific calibration parameter having been determined based in part on:
testing a glucose response of a sample of a plurality of glucose sensors to determine a representative calibration parameter of the plurality of glucose sensors, wherein the sample of the plurality of glucose sensors does not include the glucose sensor;
non-destructively determining a characteristic of the glucose sensor; and
calculating the sensor specific calibration parameter by adjusting the representative calibration parameter of the plurality of glucose sensors based upon at least the characteristic of the glucose sensor and a representative characteristic of the plurality of glucose sensors;
wherein the data processing unit is configured to use the sensor specific calibration parameter to generate calibrated levels of glucose; and
wherein the glucose sensor does not require calibration using a reference value during in vivo use of the glucose sensor, the in vivo use of the glucose sensor lasting between 3 and 14 days.