| CPC A61B 5/14532 (2013.01) [A61B 5/0002 (2013.01); A61B 5/0015 (2013.01); A61B 5/14546 (2013.01); A61B 5/1455 (2013.01); A61B 5/14865 (2013.01); A61B 5/6833 (2013.01); A61B 5/6849 (2013.01); A61B 2560/0209 (2013.01); A61B 2560/0214 (2013.01); A61B 2560/0271 (2013.01)] | 20 Claims |

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1. An in vivo analyte monitoring system, comprising:
an applicator, comprising:
an applicator assembly including a housing; and
a removable end cap secured to the applicator assembly; and
an on-body electronics device, comprising:
an analyte sensor, at least a portion of which is configured to be positioned in a body of a user and sense an analyte level in the body;
communication circuitry configured to receive a wireless transmission from a reader device according to a Bluetooth protocol; and
one or more processors coupled with a memory, the memory storing instructions that, when executed by the one or more processors, cause the one or more processors to:
determine whether the wireless transmission is part of a Bluetooth advertising sequence, and
in response to determining that the wireless transmission is part of the Bluetooth advertising sequence, change the state of the on-body electronics device from a first power mode to a second power mode, wherein the second power mode consumes more power than the first power mode,
wherein the applicator assembly is configured to releasably retain the on-body electronics device within an interior of the applicator assembly until the on-body electronics device is applied to a user.
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