US 12,350,017 B2
Method and device for determining changes in retinal and/or brain temperature
Ossi Kaikkonen, Haartmaninkatu (FI); Teemu Turunen, Haartmaninkatu (FI); Marja Pitkänen, Aalto (FI); and Ari Koskelainen, Aalto (FI)
Assigned to MACULASER OY, Helsinki (FI)
Appl. No. 17/615,289
Filed by MACULASER OY, Helsinki (FI)
PCT Filed May 29, 2020, PCT No. PCT/FI2020/050361
§ 371(c)(1), (2) Date Nov. 30, 2021,
PCT Pub. No. WO2020/240092, PCT Pub. Date Dec. 3, 2020.
Claims priority of application No. 20195461 (FI), filed on May 31, 2019.
Prior Publication US 2022/0192505 A1, Jun. 23, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 5/01 (2006.01); A61B 5/398 (2021.01); A61F 9/008 (2006.01)
CPC A61B 5/01 (2013.01) [A61B 5/398 (2021.01); A61F 9/008 (2013.01); A61F 2009/00844 (2013.01); A61F 2009/00863 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for determining changes in retinal and/or brain temperature comprising the steps of:
acquiring at least one electrical response signal from a retina in a first temperature;
acquiring at least one electrical response signal from the retina in at least a second temperature, the second temperature being different than the first temperature;
transforming at least the electrical response signal acquired in the second temperature with a plurality of different transformation parameter values resulting a plurality of different transformed signals;
comparing the different transformed signals of the electrical response signal in the second temperature to the electrical response signal and/or transformed signals acquired from the retina in the first temperature;
selecting the transformed electrical response signal which produces the highest similarity measure with the electrical response signal and/or transformed signal acquired from the retina in the first temperature; and
converting the transformation parameter value or parameter values of the selected transformed signal to a temperature, temperature difference between the first temperature and the second temperature, and/or temperature dependent indicator.