US 12,349,964 B2
Pretreatment waveform for irreversible electroporation
Allan Charles Shuros, St Paul, MN (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by Boston Scientific Scimed Inc., Maple Grove, MN (US)
Filed on Sep. 28, 2021, as Appl. No. 17/488,217.
Claims priority of provisional application 63/085,452, filed on Sep. 30, 2020.
Prior Publication US 2022/0096151 A1, Mar. 31, 2022
Int. Cl. A61B 18/12 (2006.01); A61B 18/14 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 18/1206 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/1253 (2013.01); A61B 2018/126 (2013.01); A61B 2562/0219 (2013.01)] 19 Claims
OG exemplary drawing
 
14. An electroporation ablation system for treating targeted tissue in a patient, the electroporation ablation system comprising:
an ablation catheter including:
a handle;
a shaft having a distal end; and
catheter electrodes situated at the distal end of the shaft and spatially arranged to generate electric fields in the targeted tissue in response to receiving electrical pulses; and
an electroporation generator operatively coupled to multiple electrodes including one or more of a surface patch electrode and one or more of the catheter electrodes and configured to deliver the electrical pulses in an irreversible electroporation pulse sequence that includes a preconditioning pulse sequence and an electroporation pulse sequence to the multiple electrodes, wherein the electroporation generator is configured to deliver the electroporation pulse sequence during the preconditioning pulse sequence;
wherein the preconditioning pulse sequence includes preconditioning electrical pulses configured to cause electrolysis near the targeted tissue and tetanizing skeletal muscle stimulation in the patient.