US 11,054,428 B2
Inhalable nanosensors with volatile reporters and uses thereof
Sangeeta N. Bhatia, Lexington, MA (US); Leslie Wan-Gee Chan, Somerville, MA (US); Melodi Nilgun Anahtar, Cambridge, MA (US); and Roderick Russell Kunz, Acton, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Mar. 5, 2019, as Appl. No. 16/293,390.
Claims priority of provisional application 62/638,352, filed on Mar. 5, 2018.
Prior Publication US 2019/0271704 A1, Sep. 5, 2019
Int. Cl. G01N 33/58 (2006.01); G01N 33/497 (2006.01); G01N 33/569 (2006.01); G01N 33/543 (2006.01); G01N 33/533 (2006.01); C12Q 1/37 (2006.01)
CPC G01N 33/587 (2013.01) [C12Q 1/37 (2013.01); G01N 33/497 (2013.01); G01N 33/533 (2013.01); G01N 33/54346 (2013.01); G01N 33/569 (2013.01); G01N 33/582 (2013.01); G01N 2458/20 (2013.01); G01N 2560/00 (2013.01); G01N 2800/12 (2013.01); G01N 2800/50 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A nanosensor comprising a scaffold linked to a synthetic volatile reporter via an enzymatic substrate, wherein the volatile reporter is capable of being released from the nanosensor when exposed to an enzyme present in a lung of a subject.