US 11,053,532 B2
Methods for treating polymicrobial infections
David A. Baunoch, Irvine, CA (US); Miguel F. R. Penaranda, Irvine, CA (US); Michael L. Opel, Irvine, CA (US); Maher Badir, Irvine, CA (US); and Natalie Luke, Irvine, CA (US)
Assigned to CAP DIAGNOSTICS, LLC, Irvine, CA (US)
Filed by CAP DIAGNOSTICS, LLC, Irvine, CA (US)
Filed on Apr. 14, 2020, as Appl. No. 16/848,651.
Application 16/848,651 is a continuation in part of application No. 16/216,751, filed on Dec. 11, 2018, abandoned.
Application 16/216,751 is a continuation of application No. 15/957,780, filed on Apr. 19, 2018, granted, now 10,160,991, issued on Dec. 25, 2018.
Claims priority of provisional application 63/009,337, filed on Apr. 13, 2020.
Claims priority of provisional application 62/988,186, filed on Mar. 11, 2020.
Claims priority of provisional application 62/978,149, filed on Feb. 18, 2020.
Claims priority of provisional application 62/977,637, filed on Feb. 17, 2020.
Claims priority of provisional application 62/956,923, filed on Jan. 3, 2020.
Claims priority of provisional application 62/928,815, filed on Oct. 31, 2019.
Claims priority of provisional application 62/924,614, filed on Oct. 22, 2019.
Claims priority of provisional application 62/487,395, filed on Apr. 19, 2017.
Prior Publication US 2020/0347433 A1, Nov. 5, 2020
Int. Cl. A61K 31/00 (2006.01); C12Q 1/08 (2006.01); G01N 21/59 (2006.01)
CPC C12Q 1/08 (2013.01) [G01N 21/59 (2013.01); G01N 21/5907 (2013.01); G01N 2021/593 (2013.01)] 4 Claims
OG exemplary drawing
 
1. A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of Enterococcus faecalis (E. faecalis) and Escherichia coli (E. coli), the method comprising:
a. detecting the presence of both E. faecalis and E. coli in a source of the infection obtained from the patient; and
b. administering to the patient a therapeutically effective amount of an antibiotic selected from the group consisting of: (i) the combination of amoxicillin and clavulante, (ii) the combination of ampicillin and sulbactam, (iii) levofloxacin, (iv) meropenem, (v) tetracycline and (vi) a combination of two or more of antibiotics (i)-(v);
wherein E. faecalis and E. coli together have decreased odds of resistance to one or more of the antibiotics, and wherein the antibiotics are effective for killing or inhibiting growth of E. faecalis and E. coli to treat the polymicrobial infection.