US 11,053,323 B2
Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations
Phillip Blaskovich, Salem, MA (US); Valentino Tramontano, Brockton, MA (US); Rachit Ohri, Framingham, MA (US); Joshua Kennedy, Somerville, MA (US); and Christopher M. Henry, Allston, MA (US)
Assigned to Covidien LP, Mansfield, MA (US)
Filed by Covidien LP, Mansfield, MA (US)
Filed on Nov. 7, 2016, as Appl. No. 15/344,633.
Application 15/344,633 is a continuation of application No. 13/927,316, filed on Jun. 26, 2013, granted, now 9,499,636.
Claims priority of provisional application 61/665,540, filed on Jun. 28, 2012.
Prior Publication US 2017/0051077 A1, Feb. 23, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. C08B 1/00 (2006.01); C08B 15/00 (2006.01); C08J 3/09 (2006.01); C08J 3/14 (2006.01); C08B 15/02 (2006.01); C08J 3/075 (2006.01); C08L 1/04 (2006.01)
CPC C08B 1/003 (2013.01) [C08B 15/00 (2013.01); C08B 15/005 (2013.01); C08B 15/02 (2013.01); C08J 3/075 (2013.01); C08J 3/096 (2013.01); C08J 3/14 (2013.01); C08L 1/04 (2013.01); C08J 2301/04 (2013.01)] 6 Claims
 
1. A process for forming a composition comprising:
forming an oxidized cellulose solution;
forming a cationic composition cross-linkable with the oxidized cellulose solution, the cationic composition including an aqueous solution of chitosan having a pH from about 2.0 to about 6.0; and
contacting the oxidized cellulose solution and the cationic composition at a tissue treatment site thereby forming an ionically cross-linked gel, by convergently applying the oxidized cellulose solution and the cationic composition onto the tissue treatment site.