US 11,052,177 B2
Antimicrobial polymer layers
Hyun-Su Lee, Wayne, PA (US); David M. Eckmann, Wynnewood, PA (US); and Russell Composto, Philadelphia, PA (US)
Assigned to THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Filed on Sep. 8, 2014, as Appl. No. 14/479,536.
Claims priority of provisional application 61/874,744, filed on Sep. 6, 2013.
Prior Publication US 2015/0071982 A1, Mar. 12, 2015
Int. Cl. A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61L 31/10 (2006.01); A61L 15/22 (2006.01); A61L 27/34 (2006.01); A61L 31/16 (2006.01); A61L 15/46 (2006.01); A61L 27/54 (2006.01)
CPC A61L 29/085 (2013.01) [A61L 15/225 (2013.01); A61L 15/46 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 29/16 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/404 (2013.01); A61L 2300/406 (2013.01); A61L 2420/02 (2013.01); A61L 2420/08 (2013.01)] 30 Claims
OG exemplary drawing
 
1. An article comprising a substrate comprising a surface, wherein the surface of the substrate comprises:
a first polymer layer comprising an anionic polymer,
a second polymer layer exposed to a biological tissue or a biological system comprising a cationic polymer,
wherein said cationic polymer comprises a chitosan modified with 25% to 50% quaternary ammonium salts, a chitosan modified with about 40% carboxylic acid, or a combination thereof,
wherein said first polymer layer is an end-grafted polymer brush immobilized on the surface of said substrate, and
wherein said second polymer layer overlays, directly contacts, and is covalently cross-linked to said first polymer layer,
and an anti-microbial agent sequestered in said first polymer layer,
wherein said agent is sequestered at a physiological pH, and wherein said polymers are configured to release said agent at an acidic pH.