US 11,052,175 B2
Cartilage-derived implants and methods of making and using same
Michael A. Nasert, Hazlet, NJ (US); Florence Stoffel, Whitehouse Station, NJ (US); Paul R. Williams, Boise, ID (US); and Alex Callahan, Eatontown, NJ (US)
Assigned to Musculoskeletal Transplant Foundation, Edison, NJ (US)
Filed on Aug. 15, 2016, as Appl. No. 15/236,975.
Claims priority of provisional application 62/207,146, filed on Aug. 19, 2015.
Prior Publication US 2017/0049930 A1, Feb. 23, 2017
Int. Cl. A61L 27/36 (2006.01); B29C 65/56 (2006.01); B29B 13/04 (2006.01); B29L 31/00 (2006.01)
CPC A61L 27/3612 (2013.01) [A61L 27/3654 (2013.01); B29B 13/04 (2013.01); B29C 65/565 (2013.01); A61L 2430/06 (2013.01); B29K 2995/0056 (2013.01); B29L 2031/7532 (2013.01)] 12 Claims
OG exemplary drawing
1. A cartilage-derived implant for treating a cartilage defect of cartilage, said implant being shapeable and comprising:
a plurality of milled lyophilized cartilage particles having a size not greater than 1 millimeter and a reduced water content of from 0.1 to 8.0%, by weight based on the weight of the plurality of lyophilized cartilage particles; and
a plurality of cartilage fibers which are elongated curled pieces of cartilage tissue, each having three or more laterally oriented striations,
wherein the striations of the cartilage fibers enable the cartilage fibers to entangle with one another to a greater degree than cartilage fibers without such striations and form the implant which retains its shape until reshaped and conforms to and completely fills the cartilage defect when implanted in the cartilage defect.