US 11,052,164 B2
Compositions and associated methods for radioisotope-binding microparticles
Philippe Reb, Themericourt (FR); and Celine Chaix, Paris (FR)
Assigned to Biosphere Medical, Inc., South Jordan, UT (US)
Filed by Biosphere Medical, Inc., South Jordan, UT (US)
Filed on Sep. 26, 2019, as Appl. No. 16/584,525.
Application 16/584,525 is a continuation of application No. 15/615,586, filed on Jun. 6, 2017, granted, now 10,434,200.
Application 15/615,586 is a continuation of application No. 14/207,219, filed on Mar. 12, 2014, granted, now 9,687,573, issued on Jun. 27, 2017.
Claims priority of provisional application 61/779,712, filed on Mar. 13, 2013.
Prior Publication US 2020/0023087 A1, Jan. 23, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 51/12 (2006.01)
CPC A61K 51/1244 (2013.01) [Y10T 428/2982 (2015.01)] 16 Claims
 
1. A method of preparing an embolic microsphere, comprising:
fabricating a microsphere comprising a polymerized monomer and a chelating agent, wherein the chelating agent comprises a compound of Formula I:

OG Complex Work Unit Chemistry
wherein n is between 1 and 18, inclusive;
Xa and Xb each are independently O, S or N; and
R is alkyl or H,
wherein the chelating agent is configured to chelate a radioisotope, wherein the monomer comprises at least one of an acrylate, acrylamide, or acrylic monomer, wherein the microsphere comprises a diameter ranging from about 1 micrometer to about 2000 micrometers, and wherein the microsphere is non-biodegradable and suitable for embolization wherein the microsphere comprises between about 1% and about 20% by weight of chelating agent.