US 11,052,151 B2
Diagnosis and treatment of autism spectrum disorder
Elaine Hsiao, Rowland Heights, CA (US); Sarkis K. Mazmanian, Porter Ranch, CA (US); Paul H. Patterson, Altadena, CA (US); and Sara McBride, Pasadena, CA (US)
Assigned to California Institute of Technology, Pasadena, CA (US)
Filed by California Institute of Technology, Pasadena, CA (US)
Filed on Nov. 16, 2018, as Appl. No. 16/193,724.
Application 16/193,724 is a continuation of application No. 14/012,769, filed on Aug. 28, 2013, granted, now 10,220,089.
Claims priority of provisional application 61/694,679, filed on Aug. 29, 2012.
Prior Publication US 2019/0231871 A1, Aug. 1, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/395 (2006.01); A61K 35/74 (2015.01); A61K 35/741 (2015.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01); C07K 16/18 (2006.01)
CPC A61K 39/3955 (2013.01) [A61K 35/74 (2013.01); A61K 35/741 (2013.01); C07K 16/18 (2013.01); G01N 33/6896 (2013.01); A61K 2039/505 (2013.01); G01N 2800/28 (2013.01); G01N 2800/7076 (2013.01); G01N 2800/7085 (2013.01)] 8 Claims
 
1. A method for improving behavioral performance in a subject, the method comprising:
selecting a subject that has a deficiency in behavioral performance using a test selected from the group consisting of: Autism Behavior Checklist (ABC), Autism diagnostic Interview-Revised (ADI-R), childhood autism Rating Scale (CARS), Pre-Linguistic Autism Diagnostic Observation Schedule (PL-ADOS), and a combination thereof,
wherein the subject suffers from anxiety, Fragile X, Rett syndrome, obsessive compulsive disorder, attention deficit disorder, autistic disorder (classic autism), Asperger's disorder (Asperger syndrome), pervasive developmental disorder not otherwise specified (PDD-NOS), childhood disintegrative disorder (CDD), or autism spectrum disorder (ASD),
wherein the subject has an altered level of 4-ethylphenylsulfate relative to a subject not suffering from or showing symptoms of anxiety, Fragile X, Rett syndrome, obsessive compulsive disorder, attention deficit disorder, autistic disorder (classic autism), Asperger's disorder (Asperger syndrome), PDD-NOS, CDD, or ASD; and
administering a composition comprising Bacteroides bacteria to the selected subject, wherein the Bacteroides bacteria is B. fragilis, B. thetaiotaomicron, B. vulgatus, or a mixture thereof.