US 11,052,074 B2
Process for the preparation of a pharmaceutical composition containing pirfenidone in sustained-release tablet form and its application in the regression of human chronic renal failure, breast capsular contracture and hepatic fibrosis
Juan Socorro Armendáriz Borunda, Mexico City (MX); José Agustín Rogelio Magaña Castro, Mexico City (MX); and Jorge Cervantes Guadarrama, Mexico City (MX)
Assigned to Excalibur Pharmaceuticals, Inc., New York, NY (US)
Filed by Excalibur Pharmaceuticals, Inc., New York, NY (US)
Filed on Aug. 19, 2019, as Appl. No. 16/544,643.
Application 15/831,650 is a division of application No. 15/177,760, filed on Jun. 9, 2016, granted, now 9,962,374.
Application 15/177,760 is a division of application No. 14/233,600, granted, now 9,408,836, previously published as PCT/MX2012/000067, filed on Jul. 13, 2012.
Application 16/544,643 is a continuation of application No. 15/831,650, filed on Dec. 5, 2017, granted, now 10,383,862.
Claims priority of application No. MX/A/2011/007675 (MX), filed on Jul. 19, 2011.
Prior Publication US 2020/0038386 A1, Feb. 6, 2020
Int. Cl. A61K 31/4418 (2006.01); A61K 9/20 (2006.01); A61P 25/02 (2006.01); A61P 29/00 (2006.01); A61K 31/4412 (2006.01); A61K 9/00 (2006.01); A61K 31/717 (2006.01); A61K 31/44 (2006.01)
CPC A61K 31/4418 (2013.01) [A61K 9/0053 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/2095 (2013.01); A61K 31/4412 (2013.01); A61P 25/02 (2018.01); A61P 29/00 (2018.01); A61K 31/44 (2013.01); A61K 31/717 (2013.01)] 24 Claims
 
1. A sustained-release tablet comprising pirfenidone, sodium stearyl fumarate, low viscosity hydroxypropylmethylcellulose (HPMC), high viscosity hydroxypropylmethylcellulose (HPMC), and one or more excipients, for sustained release of pirfenidone over 12 hours.