US 11,052,054 B2
Method for manufacturing a transdermal device
Spiros Fotinos, Attika (GR); Jerome Langlume, Paris (FR); and Jean Paul Caravita, Paris (FR)
Filed by INEP EUROPE SARL, Luxembourg (LU)
Filed on Apr. 19, 2017, as Appl. No. 15/491,419.
Prior Publication US 2018/0303762 A1, Oct. 25, 2018
Int. Cl. A61K 9/70 (2006.01); A61F 13/02 (2006.01)
CPC A61K 9/703 (2013.01) [A61F 13/0289 (2013.01); A61K 9/7084 (2013.01); A61F 2013/0296 (2013.01)] 7 Claims
 
1. A method for manufacturing an individual transdermal patch comprising the steps of:
providing a first web of material, the first web of material including a film layer, at least one drug-in-adhesive layer and a first release liner;
cutting a plurality of vertical lines and horizontal lines in the first web of material to delimit a plurality of segments of the first web of material;
cutting out areas of the first web of material where the first web is through-cut along horizontal lines into separable strips and kiss-cut along vertical lines down to the depth of the first release liner, the areas where the horizontal and vertical line intersect are cut out in a portion having a star shape to provide rounded corners for the plurality of segments of the first web material to delimit the plurality of segments of the first web of material;
peeling away portions of the first release liner from the plurality of segments of the first web material; and
transferring the plurality of segments of the first web material beneath the peeled away portions of the first release liner to a second web of a release liner, the first web of material is moved along at a first average velocity (V1) to a transfer station where the first web of material faces the second web of the release liner material and the second web of the release liner material moves at a second average velocity (V2), the second average velocity (V2) is greater than first average velocity (V1) to provide a predetermined spacing of the transferred plurality of segments on the second web of the release layer,
wherein the transferred plurality of segments each comprise the individual transdermal patch and wherein the step of cutting out areas of the first web further comprises cutting a piece of the first web down to a depth of the first release liner by kiss-cut to provide a strip between adjacent transdermal patches and removing the strip leaving between adjacent transdermal devices a space to facilitate the removal of the transdermal patch and transfer from the first web (V1) moving at first web velocity to the second web moving at the second web velocity (V2).