US 11,052,045 B2
Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage
Qiyong Peter Liu, Newton, MA (US); Junqing Cui, West Roxbury, MA (US); Rud Karly Lucien, Lynn, MA (US); Ryan Carney, Hudson, NH (US); Jihae Sohn, Brighton, MA (US); and Michelle Arya, Medford, MA (US)
Assigned to Velico Medical, Inc., Beverly, MA (US)
Filed by Velico Medical, Inc., Beverly, MA (US)
Filed on Dec. 19, 2016, as Appl. No. 15/383,201.
Application 15/383,201 is a continuation of application No. 14/858,539, filed on Sep. 18, 2015, granted, now 9,545,379.
Claims priority of provisional application 62/052,689, filed on Sep. 19, 2014.
Prior Publication US 2017/0100339 A1, Apr. 13, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); F26B 3/06 (2006.01); F26B 3/12 (2006.01); F26B 5/04 (2006.01); A61K 35/16 (2015.01); B01J 19/06 (2006.01); F26B 3/04 (2006.01); F26B 5/06 (2006.01); B65D 81/26 (2006.01); B65D 51/30 (2006.01)
CPC A61K 9/1682 (2013.01) [A61K 9/16 (2013.01); A61K 9/1617 (2013.01); A61K 9/1688 (2013.01); A61K 35/16 (2013.01); B01J 19/06 (2013.01); F26B 3/04 (2013.01); F26B 3/06 (2013.01); F26B 3/12 (2013.01); F26B 5/04 (2013.01); B01J 2219/00177 (2013.01); B65D 51/30 (2013.01); B65D 81/266 (2013.01); F26B 5/065 (2013.01)] 39 Claims
OG exemplary drawing
 
1. A method of producing a dried formulated plasma, the method comprising providing:
i) plasma,
ii) one or more physiologically compatible stable acidic substances, wherein said one or more stable acidic substances is an acid or acidic salt that effectuates a pH and is physiologically suitable for addition to plasma being dried or physiologically suitable for subjects into which reconstituted plasma is transfused, wherein when plasma and one or more stable acidic substances are combined, the combination creates a formulated plasma, and
iii) a plasma drying system for drying the formulated plasma
to thereby create a dried formulated plasma, wherein the concentration of the stable acidic substance is in a range between about 0.001 and about 0.050 mmol/ml in the plasma.