US 11,051,976 B2
Preservative removal from eye drops
Anuj Chauhan, Golden, CO (US); and Kuan-Hui Hsu, Gainesville, FL (US)
Assigned to University of Florida Research Foundation, Inc., Gainesville, FL (US)
Filed by University of Florida Research Foundation, Inc., Gainesville, FL (US)
Filed on Oct. 22, 2018, as Appl. No. 16/166,787.
Application 16/166,787 is a division of application No. 15/502,876, granted, now 10,123,904, previously published as PCT/US2015/044782, filed on Aug. 12, 2015.
Claims priority of provisional application 62/160,233, filed on May 12, 2015.
Claims priority of provisional application 62/036,670, filed on Aug. 13, 2014.
Prior Publication US 2019/0117450 A1, Apr. 25, 2019
Int. Cl. A61F 9/00 (2006.01); A61J 1/05 (2006.01); A61J 1/14 (2006.01); A61K 9/00 (2006.01); A61K 31/382 (2006.01); A61K 31/5377 (2006.01); A61K 31/5575 (2006.01); A61K 31/573 (2006.01); A61K 47/18 (2017.01); B01D 15/00 (2006.01); B01J 20/26 (2006.01); C08J 9/28 (2006.01); B65D 51/24 (2006.01)
CPC A61F 9/0008 (2013.01) [A61J 1/05 (2013.01); A61J 1/1456 (2015.05); A61K 9/0048 (2013.01); A61K 31/382 (2013.01); A61K 31/5377 (2013.01); A61K 31/5575 (2013.01); A61K 31/573 (2013.01); A61K 47/186 (2013.01); B01D 15/00 (2013.01); B01J 20/261 (2013.01); C08J 9/286 (2013.01); B65D 51/24 (2013.01); C08J 2205/022 (2013.01); C08J 2205/044 (2013.01); C08J 2207/10 (2013.01); C08J 2333/14 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of administering an ophthalmic agent, comprising:
applying pressure to a compressible bottle, wherein an ophthalmic agent-containing solution, emulsion, or suspension comprising at least one ophthalmic agent and at least one preservative is forced through a preservative removing device, wherein at least 50 percent of the preservative is removed from the solution, emulsion, or suspension, and wherein at least 50 percent of the ophthalmic agent is retained by the solution, emulsion, or suspension; and
wherein the compressible bottle comprises a preservative removing device at the outlet of the compressible bottle, the preservative removing device comprising a porous polymeric matrix, wherein the porous polymeric matrix comprises a material with a hydraulic permeability greater than 0.01 Da, wherein the porous polymeric matrix rapidly and selectively removes a preservative from the solution, emulsion, or suspension.