US 11,051,699 B2
Method and system for estimating fractional fat content of an object of interest
Christopher Nelson Davis, Ann Arbor, MI (US); Jang Hwan Cho, Ann Arbor, MI (US); and Michael M. Thornton, London (CA)
Assigned to ENDRA Life Sciences Inc., Ann Arbor, MI (US)
Filed by ENDRA Life Sciences Inc., Ann Arbor, MI (US)
Filed on Dec. 24, 2018, as Appl. No. 16/231,895.
Prior Publication US 2020/0196872 A1, Jun. 25, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/20 (2006.01)
CPC A61B 5/0093 (2013.01) [A61B 5/201 (2013.01); A61B 5/4244 (2013.01); A61B 5/489 (2013.01); A61B 5/4872 (2013.01); A61B 5/7235 (2013.01); A61B 5/7278 (2013.01); A61B 2576/02 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for estimating fractional fat content of an object of interest, the method comprising:
(i) directing, using a radio frequency (RF) applicator, one or more RF energy pulses into a region of interest, the region of interest comprising the object of interest and at least one reference that are separated by at least one boundary;
(ii) detecting, using an acoustic receiver, at least one bipolar acoustic signal generated in the region of interest in response to the RF energy pulses and processing the at least one bipolar acoustic signal to determine a peak-to-peak amplitude thereof;
(iii) adjusting an impedance of the RF applicator to enhance at least one metric of bipolar acoustic signals generated in the region of interest in response to RF energy pulses generated by the adjusted RF applicator; and
(iv) estimating fractional fat content of the object of interest based on the adjusted impedance of the RF applicator.