US 11,051,692 B2
Optical instrument for measuring the density of the macular pigment in the eye and associated method
Pablo Artal Soriano, Murcia (ES); Harilaos Ginis, Murcia (ES); Alexandros Pennos, Murcia (ES); and Dimitrios Christaras, Murcia (ES)
Assigned to UNIVERSIDAD DE MURCIA, Murcia (ES)
Appl. No. 16/324,677
Filed by UNIVERSIDAD DE MURCIA, Murcia (ES)
PCT Filed Jun. 16, 2017, PCT No. PCT/ES2017/070442
§ 371(c)(1), (2) Date Feb. 11, 2019,
PCT Pub. No. WO2018/007661, PCT Pub. Date Jan. 11, 2018.
Claims priority of application No. 201630921 (ES), filed on Jul. 6, 2016.
Prior Publication US 2019/0298170 A1, Oct. 3, 2019
Int. Cl. A61B 3/12 (2006.01); A61B 3/14 (2006.01); A61B 3/10 (2006.01); A61B 3/00 (2006.01)
CPC A61B 3/12 (2013.01) [A61B 3/0008 (2013.01); A61B 3/14 (2013.01)] 11 Claims
OG exemplary drawing
 
1. An optical instrument for measuring and recording response signals from an eye of a subject that can be used to determine the density of macular pigment in the eye, the eye comprising a fundus with a macular area and a peripheral area, the light optical instrument comprising:
(a) at least one light source comprising a central part and a peripheral part, the at least one light source emitting light that is modulated at four different frequencies f1, f2, f3 and f4 corresponding to a first green light emitted from the central part at modulated frequency f1; a second green light emitted from the peripheral part at modulated frequency f2, a first blue light emitted from the central part at modulated frequency f3 and a second blue light emitted from the peripheral part at modulated frequency f4;
(b) first means for controlling a path of the light emitted from the at least one light source so that the first green light and the first blue light emitted from the central part of the at least one light source is directed onto the macular area of the eye and simultaneously the second green light and the second blue light emitted from the peripheral part of the at least one light source is directed onto the peripheral area of the eye, the first means comprising a plurality of lenses disposed between the at least one light source and the eye and a first diaphragm conjugated to a pupil plane of the eye;
(c) a photodetector for receiving the light emitted from the at least one light source that is reflected from the macular and peripheral areas and for recording data relative thereto; and
(d) second means for directing light reflected from the macular and peripheral areas to the photodetector and for eliminating light reflected from ocular areas of the eye other than the macular and the peripheral areas, the second means comprising a mirror, a second diaphragm conjugated to the pupil plane of the eye and at least one lens disposed between the second diaphragm and the photodetector.