US 12,349,610 B2
Apparatus and method for biomarker detection
David Robert Sime Cumming, East Dunbartonshire (GB); and Valerio Francesco Annese, Glasgow (GB)
Assigned to The University Court of the University of Glasgow, Glasgow (GB)
Appl. No. 17/917,965
Filed by THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW, Glasgow (GB)
PCT Filed Apr. 8, 2021, PCT No. PCT/EP2021/059158
§ 371(c)(1), (2) Date Oct. 10, 2022,
PCT Pub. No. WO2021/204936, PCT Pub. Date Oct. 14, 2021.
Claims priority of application No. 2005170 (GB), filed on Apr. 8, 2020.
Prior Publication US 2023/0160850 A1, May 25, 2023
Int. Cl. G01N 27/414 (2006.01); B01L 3/00 (2006.01)
CPC G01N 27/4148 (2013.01) [B01L 3/5027 (2013.01); B01L 2300/0663 (2013.01); B01L 2400/0406 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A detection apparatus for detecting a biomarker in a biological sample, the detection apparatus comprising:
a sample receiving module arranged to receive the biological sample in a reaction zone, the reaction zone comprising:
a test region that is sensitive to presence of the biomarker in the biological sample;
a positive control region that is sensitive to presence of the biomarker in the biological sample, and which includes a pre-loaded portion of the biomarker; and
a negative control region that is not sensitive to presence of the biomarker in the biological sample; and
a CMOS-based sensor unit configured to:
independently detect a property of each of the test region, the positive control region, and the negative control region, and
output a respective detection signal for each of the test region, the positive control region, and the negative control region,
wherein the CMOS-based sensor unit is communicable with an analysis module that is configured to determine information related to a presence of the biomarker in the biological sample using the respective detection signals from the test region, the positive control region, and the negative control region.