| CPC G16H 20/10 (2018.01) [G06N 5/022 (2013.01); G16H 10/20 (2018.01); G16H 30/20 (2018.01); G16H 50/20 (2018.01); G16H 50/70 (2018.01); G16H 70/40 (2018.01)] | 8 Claims |
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1. A computer-implemented method for dosing single and multiple drugs for an individual patient, by
a healthcare professional collecting and inputting data from the individual patient including drugs to be taken by the patient into a database with a central artificial intelligence (AI) system stored on computer readable media,
the central AI system analyzing the individual patient data in view of dosing criteria established based on outside patient data from clinical trial databases, electronic medical records, pharmaceutical companies, private databases, and contract research organizations (CROs), wherein outside patients experienced safety and efficacy,
the central AI system creating features from data points of outside patient data variables that affect drug metabolism, the central AI system extracting all the features and creating a model using the features from the outside patient data variables relating dosing to patient condition of the outside patients and effect of drugs on the condition that affect efficacy and toxicity of all drugs taken by the individual patient, the variables including age of patient, weight of patient, known side effects of drugs alone and in combinations with other drugs with the outside patients, known toxicity range as related to median effective dose (ED 50) and dose response points, efficacy ranges, and chronic treatment effect versus acute treatment with outside patients, the central AI system identifying nearest neighbors of the outside patients having similar patient data and/or underwent a treatment plan with similar drug combinations to the individual patient and identifying related clinical trial data with a K-Nearest Neighbor algorithm, the central AI system employing a combination of artificial intelligence techniques, both supervised and unsupervised, including model logic of classifiers and expert rules that are prepopulated by practitioners and published research and are assigned a degree of truth, wherein the central AI system is unique to given inputs and is trained on demand to emphasize individuality of the individual patient and symptoms, the central AI system assigning confidence and weight to the individual patient data, the related clinical trial data, and the outside patient data variables, wherein patient data includes continuous values and discrete values, the central AI system using the classifiers and the expert rules implemented in series, the central AI system comparing the individual patient data to neighboring patient data with weighting schemes, the central AI system calculating the classifiers and model over the range of all doses considered by the model for the individual patient, wherein for each dosage, classifications with confidence intervals are calculated, the model is ran using the dosages mapped out to the classifiers, the outputs from the classifiers and the model are weighted and combined to determine an optimal dose for each drug, and
the central AI system determining a dose or doses of the single or multiple drugs, respectively, for each drug taken by the individual patient and maximizing therapeutic effect while minimizing adverse effects for the combination of drugs taken, the central AI system producing clinical outputs of a recommended dosing range of the single or multiple drugs and in real time communication with a dispensing device to administer the drugs, and displaying the dose in a readable report for a practitioner.
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