US 12,346,135 B2
Bioprocess fluid mixing system
Klaus Gebauer, Uppsala (SE)
Assigned to Cytiva Sweden AB, Uppsala (SE)
Appl. No. 17/777,590
Filed by Cytiva Sweden AB, Uppsala (SE)
PCT Filed Dec. 11, 2020, PCT No. PCT/EP2020/085767
§ 371(c)(1), (2) Date May 17, 2022,
PCT Pub. No. WO2021/122376, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 1918890 (GB), filed on Dec. 19, 2019.
Prior Publication US 2023/0014015 A1, Jan. 19, 2023
Int. Cl. G05D 11/13 (2006.01); G01N 30/32 (2006.01); G01N 30/34 (2006.01); G01N 30/88 (2006.01)
CPC G05D 11/139 (2013.01) [G01N 30/32 (2013.01); G01N 30/34 (2013.01); G01N 2030/347 (2013.01); G01N 2030/8809 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A bioprocess fluid mixing system, said fluid mixing system comprising:
at least two fluid inlets, configured for providing a first fluid into the fluid mixing system through a first fluid inlet and for providing a second fluid into the fluid mixing system through a second fluid inlet;
at least one valve arrangement, where a first valve arrangement is in fluid communication with at least both the first fluid inlet and the second fluid inlet;
at least two pumps, where a first pump is in selective fluid communication with at least both the first and the second fluid inlets via the first valve arrangement and a second pump is in fluid communication with at least one of the first and second fluid inlet; and
a common fluid outlet which is in fluid communication with at least an outlet of the first pump and an outlet of the second pump,
wherein pump rates of the at least two pumps and valve positions in the at least one valve arrangement are configured to be controllable by a control system such that mixing of at least a first fluid from the first fluid inlet and a second fluid from the second fluid inlet can be performed to a requested mixing of the at least two fluids and to a requested combined fluid flow rate at the common fluid outlet, and
wherein said fluid mixing system is further operable to mix fluids both upstream and downstream of the first and second pumps.
 
10. A method for mixing fluids in a bioprocess fluid mixing system according to claim 1, wherein said method comprises controlling pump rates of the at least two pumps and valve positions in the at least one valve arrangement such that mixing of the at least a first fluid from the first fluid inlet and a second fluid from the second fluid inlet to a requested mixing of the at least two fluids and to a requested combined fluid flow rate at the common fluid outlet can be performed both upstream of the first pump and downstream of the pumps.