US 12,345,699 B2
Contactless inspection of reproductive cellular structures using optical measurement of biomechanical properties
Jang Lawrence Hyun Yoo, Los Angeles, CA (US); Kwangsup Shin, Bedford, MA (US); and Yen-Wei Lin, Natick, MA (US)
Assigned to Intelon Optics, Inc., Lexington, MA (US)
Filed by Intelon Optics, Inc., Lexington, MA (US)
Filed on Mar. 1, 2021, as Appl. No. 17/188,972.
Claims priority of provisional application 62/982,368, filed on Feb. 27, 2020.
Prior Publication US 2021/0270810 A1, Sep. 2, 2021
Int. Cl. G01N 33/483 (2006.01); G01N 21/63 (2006.01); G01N 33/50 (2006.01); G06F 17/18 (2006.01)
CPC G01N 33/4833 (2013.01) [G01N 21/636 (2013.01); G06F 17/18 (2013.01); G01N 2021/638 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of measuring at least one biomechanical property of a reproductive cellular structure, the method comprising:
illuminating the reproductive cellular structure with radiation;
detecting at least a portion of radiation scattered from the illuminated reproductive cellular structure;
analyzing a frequency spectrum of the detected scattered radiation to identify at least one Brillouin frequency shift in the frequency spectrum;
obtaining a modulus of elasticity of at least a portion of the reproductive cellular structure based on the at least one Brillouin frequency shift; and
determining viability of the reproductive cellular structure based on the modulus of elasticity.