US 12,345,672 B2
Methods of correcting for uncompensated resistances in the conductive elements of biosensors, as well as devices and systems incorporating the same
Terry A. Beaty, Indianapolis, IN (US)
Assigned to Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed by Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed on Apr. 18, 2019, as Appl. No. 16/388,623.
Application 16/388,623 is a continuation of application No. PCT/US2017/049800, filed on Sep. 1, 2017.
Claims priority of provisional application 62/411,727, filed on Oct. 24, 2016.
Prior Publication US 2020/0025707 A1, Jan. 23, 2020
Int. Cl. G01N 27/327 (2006.01); A61B 5/145 (2006.01); G01N 27/02 (2006.01); G01N 33/49 (2006.01)
CPC G01N 27/3274 (2013.01) [A61B 5/14532 (2013.01); G01N 27/028 (2013.01); G01N 33/49 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A method of compensating, correcting or minimizing uncompensated resistances in a biosensor for use in determining an analyte concentration, comprising:
measuring, with a measuring circuit in a measuring device, an electrical resistance of a compensation loop formed in a first electrode or a second electrode of the biosensor that is electrically connected to the measuring circuit;
identifying, with the measuring circuit and a processor in the measuring device, a sheet resistance value for a square region having a predetermined size within the compensation loop based on the electrical resistance and a ratio between the predetermined size of the square region and a predetermined total size of the compensation loop;
identifying, with the processor, an uncompensated electrical resistance value of the first electrode based on the sheet resistance value of the square region, a first predetermined plurality of the square regions that correspond to a connecting portion of the first electrode, and a second predetermined plurality of the square regions that correspond to an active portion of the first electrode, wherein the connecting portion and the active portion of the first electrode are located outside of the compensation loop;
applying, with the measuring circuit, an electrical test sequence to the first electrode and the second electrode after a fluid sample is applied to a reagent that contacts the active portion of the first electrode; and
identifying, with the measuring circuit and the processor, a level of an analyte in the fluid sample based at least in part on responses received from the electrical test sequence and a corrected impedance value corresponding to an impedance between the first electrode and the second electrode, wherein the processor generates the corrected impedance value based on a subtraction of the uncompensated electrical resistance of the first electrode from a real component of a measured impedance value between the first electrode and the second electrode.