US 12,345,668 B2
Measuring apparatus for the online measurement of at least one property of process liquids at at least two different flow rates for the production of a medical liquid
Jürgen Schwerdhöfer, Marktheidenfeld (DE); Stefan Eberlein, Höchberg (DE); and Patrick Bessler, Erlenbach (DE)
Assigned to VIVONIC GMBH, Sailauf (DE)
Appl. No. 18/563,527
Filed by VIVONIC GMBH, Sailauf (DE)
PCT Filed May 27, 2022, PCT No. PCT/EP2022/064406
§ 371(c)(1), (2) Date Nov. 22, 2023,
PCT Pub. No. WO2022/248664, PCT Pub. Date Dec. 1, 2022.
Claims priority of application No. 10 2021 113 782.9 (DE), filed on May 27, 2021.
Prior Publication US 2024/0241069 A1, Jul. 18, 2024
Int. Cl. G01N 27/08 (2006.01); A61M 1/16 (2006.01); G01N 27/74 (2006.01)
CPC G01N 27/08 (2013.01) [A61M 1/1657 (2022.05); A61M 1/1668 (2014.02); G01N 27/74 (2013.01); A61M 2205/3317 (2013.01); A61M 2205/3368 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A measuring apparatus for the online measurement of at least one property of process liquids at least two different flow rates and during the production of a medical liquid, comprising:
a. a tank for receiving the process liquid, wherein the tank has an outflow,
b. a hollow accumulation vessel which
i. is arranged within the tank, in a side wall of the tank or on a side wall of the tank,
ii. depending on the fill level in the tank can have process liquid pass therethrough, can be entirely filled by process liquid or can be partly filled by process liquid,
iii. comprises at least one lower opening, which is arranged in the lower region of the hollow accumulation vessel and fluidically connected to the interior of the tank, and through which opening process liquid stored in the hollow accumulation vessel is able to flow into the tank in the case where a fill level of the tank is lower than the fill level in the hollow accumulation vessel,
iv. comprises at least one upper opening, which is arranged in the upper region of the accumulation vessel and fluidically connected to the interior of the tank such that additionally process liquid can overflow out of the hollow accumulation vessel through the at least one upper opening into the tank when the fill level of the process liquid in the hollow accumulation vessel reaches up to the at least one upper opening,
v. wherein the upper region is located above the lower region,
vi. wherein the sum of the cross sections of the at least one upper openings is at least ten times as large as the sum of the cross sections of the at least one lower openings,
c. a sensor for measuring at least one property of the process liquid, which sensor is arranged in the hollow accumulation vessel in such a way that it can be in contact with the process liquid when process liquid accumulates in the hollow accumulation vessel,
d. at least two conduits are equipped with control valves for feeding at least two different process liquids into the tank,
e. at least two means are provided for controlling the feed or discharge of process liquids into the tank through control valves,
f. a controller configured to capture the measurement values of the sensor and control the valves.