US 12,344,860 B2
Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
Robert Lane Smith, Palo Alto, CA (US); Laurence J. B. Tarrant, Northhampton, MA (US); Akihiko Kusanagi, Brookline, MA (US); and Hans P. I. Claesson, Wayland, MA (US)
Assigned to Ocugen, Inc., Malvern, PA (US)
Filed by Ocugen, Inc., Malvern, PA (US)
Filed on Jan. 22, 2021, as Appl. No. 17/156,062.
Application 17/156,062 is a continuation of application No. 16/706,372, filed on Dec. 6, 2019, granted, now 10,900,017.
Application 16/706,372 is a continuation of application No. 15/641,773, filed on Jul. 5, 2017, abandoned.
Application 15/641,773 is a continuation of application No. 14/577,610, filed on Dec. 19, 2014, granted, now 9,701,940, issued on Jul. 11, 2017.
Application 14/577,610 is a continuation of application No. 11/523,833, filed on Sep. 19, 2006, granted, now 8,921,109, issued on Dec. 30, 2014.
Claims priority of provisional application 60/718,714, filed on Sep. 19, 2005.
Prior Publication US 2021/0246418 A1, Aug. 12, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 5/00 (2006.01); A61F 2/30 (2006.01); A61L 27/24 (2006.01); A61L 27/38 (2006.01); A61L 27/56 (2006.01); C12N 5/077 (2010.01); A61F 2/08 (2006.01); A61F 2/38 (2006.01)
CPC C12N 5/0068 (2013.01) [A61L 27/24 (2013.01); A61L 27/3817 (2013.01); A61L 27/3843 (2013.01); A61L 27/56 (2013.01); C12N 5/0655 (2013.01); A61F 2/08 (2013.01); A61F 2002/30062 (2013.01); A61F 2/30756 (2013.01); A61F 2/3872 (2013.01); A61F 2210/0004 (2013.01); A61F 2310/00365 (2013.01); A61L 2400/18 (2013.01); A61L 2430/06 (2013.01); A61L 2430/10 (2013.01); C12N 2533/54 (2013.01); C12N 2535/00 (2013.01)] 13 Claims
 
1. A collagen-based cell-support matrix having narrowly defined and uniformly vertically and non-randomly organized porosity and pore density wherein said matrix is prepared from a collagen-based biocompatible material, wherein said porosity is determined by pore size and wherein said pore size is substantially homogeneous in diameter.