US 12,344,827 B2
Automatized, programmable, high-throughput tissue culture and analysis systems and methods
Vahid Serpooshan, Atlanta, GA (US); Ayda Melika, Atlanta, GA (US); and Amir Pourmorteza, Atlanta, GA (US)
Assigned to Emory University, Atlanta, GA (US)
Appl. No. 17/260,946
Filed by Emory University, Atlanta, GA (US)
PCT Filed Jul. 17, 2019, PCT No. PCT/US2019/042295
§ 371(c)(1), (2) Date Jan. 15, 2021,
PCT Pub. No. WO2020/018725, PCT Pub. Date Jan. 23, 2020.
Claims priority of provisional application 62/699,478, filed on Jul. 17, 2018.
Prior Publication US 2021/0324315 A1, Oct. 21, 2021
Int. Cl. C12M 1/00 (2006.01); C12M 1/36 (2006.01); C12M 3/06 (2006.01)
CPC C12M 23/16 (2013.01) [C12M 23/38 (2013.01); C12M 29/00 (2013.01); C12M 31/02 (2013.01); C12M 41/48 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A culture analysis system comprising:
a culture device including a cover configured to be secured to a main body, the main body including one or more chambers configured to hold one or more samples;
the cover including:
a plurality of regions configured to overlap with the chambers of the main body when the cover is secured to the main body so that each region corresponds to a chamber of the main body;
a fluidic pathway disposed in each region and configured be in fluidic communication with a corresponding chamber, each fluidic pathway including a fluid inlet and a fluid outlet disposed in each region;
an optical pathway disposed in each region for the corresponding chamber;
a detection window disposed in each region for the corresponding chamber; and
a plurality of optical fibers and one or more groups of optical ports disposed on a first side of the cover;
each optical pathway for each region including one or more of the plurality of optical fibers that extend between the detection window and an optical port of the one or more groups of optical ports for each region.