US 12,344,693 B2
Lipid-polymer based complexation and delivery of nucleic acids
Sankaran Thayumanavan, Amherst, MA (US); and Kingshuk Dutta, Amherst, MA (US)
Assigned to University of Massachusetts, Westborough, MA (US)
Filed by University of Massachusetts, Boston, MA (US)
Filed on Aug. 22, 2022, as Appl. No. 17/892,637.
Application 17/892,637 is a division of application No. 16/849,943, filed on Apr. 15, 2020, granted, now 11,434,317.
Claims priority of provisional application 62/849,353, filed on May 17, 2019.
Claims priority of provisional application 62/834,939, filed on Apr. 16, 2019.
Prior Publication US 2023/0081736 A1, Mar. 16, 2023
Int. Cl. C08F 299/04 (2006.01); A61K 47/54 (2017.01); A61K 47/58 (2017.01); C08F 220/38 (2006.01); B82Y 5/00 (2011.01)
CPC C08F 299/04 (2013.01) [A61K 47/543 (2017.08); A61K 47/58 (2017.08); C08F 220/385 (2020.02); B82Y 5/00 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A molecular assembly, comprising:
a crosslinked polymer-nucleic acid complex comprising a nucleic acid encapsulated in a crosslinked polymer network; and
a coating on the crosslinked polymer-nucleic acid complex, wherein the coating comprises a zwitterionic lipid and a PEGylated lipid.