US 12,344,649 B2
Modulators of parathyroid hormone receptor (PTHR1)
Jordi Mata-Fink, Happy Valley, OR (US); Le Phuong Ngo, Belmont, MA (US); Gevorg Grigoryan, Arlington, MA (US); Craig Owen MacKenzie, Bradford, VT (US); and Kristen Park Hopson, Lincoln, MA (US)
Assigned to Flagship Pioneering Innovations VI, LLC, Cambridge, MA (US)
Appl. No. 17/633,764
Filed by Flagship Pioneering Innovations VI, LLC, Cambridge, MA (US)
PCT Filed Aug. 7, 2020, PCT No. PCT/US2020/045517
§ 371(c)(1), (2) Date Feb. 8, 2022,
PCT Pub. No. WO2021/030222, PCT Pub. Date Feb. 18, 2021.
Claims priority of provisional application 62/884,703, filed on Aug. 9, 2019.
Prior Publication US 2022/0298217 A1, Sep. 22, 2022
Int. Cl. C07K 14/635 (2006.01)
CPC C07K 14/635 (2013.01) 13 Claims
 
1. A polypeptide that specifically binds Parathyroid Hormone Receptor (PTHR), wherein the polypeptide comprises a synthetic parathyroid hormone (sPTH), wherein the sPTH comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 102-106 and SEQ ID NOs: 132-155.