US 12,344,632 B2
System and method for solution phase gap peptide synthesis
Guigen Li, Lubbock, TX (US); and Cole Seifert, Lubbock, TX (US)
Assigned to Texas Tech University System, Lubbock, TX (US)
Filed by Texas Tech University System, Lubbock, TX (US)
Filed on Feb. 10, 2021, as Appl. No. 17/172,732.
Application 17/172,732 is a division of application No. 15/739,391, granted, now 10,947,267, previously published as PCT/US2016/068112, filed on Dec. 21, 2016.
Claims priority of provisional application 62/270,432, filed on Dec. 21, 2015.
Prior Publication US 2021/0171569 A1, Jun. 10, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07F 9/53 (2006.01); C07K 1/06 (2006.01)
CPC C07K 1/061 (2013.01) [C07F 9/5325 (2013.01)] 1 Claim
 
1. A protecting group for Group Assisted Purification (GAP) peptide synthesis selected from the group consisting of:

OG Complex Work Unit Chemistry
wherein
wherein for 1B, 1C, and 1E, R is selected from the group consisting of: H, Me, and OMe;
wherein for 1D, R is selected from the group consisting of: H and 2, 3, or 4 OMe, except that R is not H in every position;
wherein for 1B and 1C, Y is selected from the group consisting of: O, S, and NH, except that for 1B when R=H, then Y is S; and
wherein for 1C, X is selected from the group consisting of: S and NH,
wherein for 1E, X is selected from the group consisting of: O, S, and NH, except that for 1E when R=H, X is not O.