| CPC C07D 491/056 (2013.01) | 12 Claims |
|
1. A compound selected from among a heterotricyclic compound of the following Formula 1, a pharmaceutically acceptable salt thereof, an optical isomer thereof, and a hydrate thereof:
 wherein:
R1 is a 5- to 6-membered aromatic heterocyclyl containing 1 to 3 heteroatoms independently selected from the group consisting of N, O and S in a ring thereof, wherein the 5- to 6-membered aromatic heterocyclyl containing 1 to 3 heteroatoms independently selected from the group consisting of N, O and S in the ring thereof is unsubstituted or substituted with one to three independently selected from Group A below;
L is a bond, C1-6 alkylene, or oxy (C1-6)alkylene;
R2 is C3-6 cycloalkyl; substituted with NR20R21, wherein R20 and R21 are each independently H, formyl, C1-6 alkyl, or substituted or unsubstituted C1-6 alkylcarbonyl;
R3 is C1-6 alkyl;
R4 is H, a halogen, or a C1-6 alkyl containing 0 to 3 halogen atoms;
R5 is C1-6 alkyl or C1-6 alkoxy;
R6 is C1-6 alkyl;
Group A comprises a halogen, C1-6 alkyl, C1-6 alkoxy, and a 5 to 6-membered aliphatic heterocyclyl containing 1 or 2 heteroatoms independently selected from the group consisting of N, O and S in a ring thereof, wherein the C1-6 alkyl, the C1-6 alkoxy and the 5 to 6-membered aliphatic heterocyclyl are unsubstituted or substituted with one to three independently selected from Group B below; and
Group B comprises a halogen, C1-6 alkyl, and a 5 to 6-membered aliphatic heterocyclyl containing 1 or 2 heteroatoms independently selected from the group consisting of N, O and S in a ring thereof.
|