US 12,344,596 B2
Solid forms of (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine and salts thereof
Qun Li, Newark, DE (US); Wenxue Wu, Princeton Junction, NJ (US); and Matthew Mangzhu Zhao, Edison, NJ (US)
Assigned to LEXICON PHARMACEUTICALS, INC., The Woodlands, TX (US)
Filed by Lexicon Pharmaceuticals, Inc., The Woodlands, TX (US)
Filed on Feb. 24, 2023, as Appl. No. 18/114,104.
Claims priority of provisional application 63/315,507, filed on Mar. 1, 2022.
Prior Publication US 2023/0357182 A1, Nov. 9, 2023
Int. Cl. A61P 25/04 (2006.01); A61K 9/28 (2006.01); A61K 31/444 (2006.01); A61P 29/00 (2006.01); C07D 213/65 (2006.01); C07D 401/04 (2006.01)
CPC C07D 401/04 (2013.01) [A61K 9/28 (2013.01); A61K 31/444 (2013.01); A61P 29/00 (2018.01); C07B 2200/13 (2013.01)] 11 Claims
 
1. A crystalline compound, which is crystalline(S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-aminium dihydrogen phosphate (Compound K):

OG Complex Work Unit Chemistry
having an XPRD pattern comprising peaks at one or more of about 4.81, 5.99, 7.44, 7.89, 11.66, 14.85, 15.77, 19.19, 20.86, 21.65, 23.96, 24.48, or 24.73 degrees 2-theta.