US 12,344,572 B2
Cationic lipids and transfection methods
Matthew Angel, Cambridge, MA (US); Franklin Kostas, Cambridge, MA (US); and Christopher Rohde, Cambridge, MA (US)
Assigned to Factor Bioscience Inc., Cambridge, MA (US)
Filed by Factor Bioscience Inc., Cambridge, MA (US)
Filed on Jul. 3, 2020, as Appl. No. 16/920,556.
Claims priority of provisional application 63/023,654, filed on May 12, 2020.
Claims priority of provisional application 62/880,435, filed on Jul. 30, 2019.
Claims priority of provisional application 62/870,245, filed on Jul. 3, 2019.
Prior Publication US 2021/0009505 A1, Jan. 14, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 215/24 (2006.01); A61K 9/00 (2006.01); A61K 9/10 (2006.01); A61K 47/54 (2017.01)
CPC C07C 215/24 (2013.01) [A61K 9/0021 (2013.01); A61K 9/10 (2013.01); A61K 47/543 (2017.08)] 11 Claims
 
1. A compound of Formula (V)

OG Complex Work Unit Chemistry
wherein
R21, R23, and R24 are independently selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxyalkyl, C5-10 aryl, 5- to 10-membered heteroaryl, or C3-6 cycloalkyl;
n is an integer from 1 to 20;
m is 6, 7, 8, 9, or 10;
p is 1, 2, 3, or 4;
q is 1, 2, 3, 4, or 5; and
r is 1, 2, 3, 4, 5, or 6.