US 12,343,728 B2
Thermally controlled reagent release
Viktor Shkolnikov, Palo Alto, CA (US); and Chien-Hua Chen, Corvallis, OR (US)
Assigned to Hewlett-Packard Development Company, L.P., Spring, TX (US)
Filed by Hewlett-Packard Development Company, L.P., Spring, TX (US)
Filed on Jan. 25, 2023, as Appl. No. 18/101,513.
Application 18/101,513 is a continuation of application No. 16/605,780, granted, now 11,577,252, previously published as PCT/US2018/029737, filed on Apr. 27, 2018.
Prior Publication US 2023/0166264 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01); B01L 7/00 (2006.01); G01N 33/543 (2006.01)
CPC B01L 7/52 (2013.01) [B01L 3/502761 (2013.01); G01N 33/54386 (2013.01); B01L 2300/12 (2013.01); B01L 2300/165 (2013.01); B01L 2300/1827 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/086 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A system, comprising:
an array of releasing features, each releasing feature being configured to selectively cause degradation of a thermally degradable shell of a capsule enclosing a primary antibody to release the primary antibody, each releasing feature configured to generate thermal energy to facilitate degradation of the shell;
an array of immobilized secondary antibodies including at least two types of secondary antibodies, each type of secondary antibody corresponding to a different primary antibody; and
a detection portion configured to detect the primary antibody bound to an antigen, the antigen being bound to a secondary antibody in the array of immobilized secondary antibodies.