| CPC A61N 1/36062 (2017.08) [A61N 1/36171 (2013.01); A61N 1/36157 (2013.01); A61N 1/36175 (2013.01)] | 26 Claims |

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1. A method of treating a patient having sensation loss associated with diabetic neuropathy, the patient having a first subset of neurons and a second subset of neurons, with at least the second subset of neurons demonstrating a pathological afferent neural response to a sensory input, the method comprising:
at least partially in response to identifying that the second subset of neurons demonstrate the pathological afferent neural response to a sensory input, programming a signal generator to deliver, via at least one implanted signal delivery element, a paresthesia-free electrical signal having a frequency within a frequency range of from about 200 Hz to about 100 kHz to the patient's spinal cord,
wherein the paresthesia-free electrical signal activates one or more neurons of the first subset of neurons within the spinal cord to modify a state of one or more neurons of the second subset of neurons and thereby increase afferent neural activity generated in the one or more neurons of the second subset of neurons in response to a sensory input.
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