US 12,343,510 B1
Prefilled syringe with pegfilgrastim having optimized dose and methods related thereto
Florence Roger, Mont-sur-Rolle (CH); Fabien Vaudant, Valleiry (FR); Thierry Rimlinger, L'Isle d'Abeau (FR); Christian Ebert, Frankfurt (DE); Rodrigue Chatton, Echichens (CH); Alexander Degen, Bad Homburg (DE); Kevin Reitz, Florstadt (DE); and Torsten Brandenburger, Reichelsheim (DE)
Assigned to FRESENIUS KABI DEUTSCHLAND GMBH, Bad Homburg (DE)
Filed by FRESENIUS KABI DEUTSCHLAND GMBH, Bad Homburg (DE)
Filed on Feb. 8, 2023, as Appl. No. 18/107,386.
Application 18/107,386 is a continuation of application No. 17/198,404, filed on Mar. 11, 2021, granted, now 11,602,598.
Claims priority of provisional application 63/071,228, filed on Aug. 27, 2020.
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/535 (2006.01); A61K 38/19 (2006.01); A61K 47/10 (2017.01); A61M 5/178 (2006.01); A61M 5/31 (2006.01); A61M 5/315 (2006.01); A61K 38/18 (2006.01)
CPC A61M 5/31525 (2013.01) [A61K 38/193 (2013.01); A61K 47/10 (2013.01); A61M 5/178 (2013.01); A61M 5/3129 (2013.01); C07K 14/535 (2013.01); A61K 38/18 (2013.01); A61M 2005/3114 (2013.01); A61M 2005/31516 (2013.01); A61M 2202/0007 (2013.01); A61M 2207/10 (2013.01)] 5 Claims
 
1. A method of filling a device from a prefilled syringe, comprising:
providing a prefilled syringe having a barrel, stopper and plunger, the barrel containing 645 to 660 microliters of pegfilgrastim solution, wherein the prefilled syringe has a dead volume of 0.6 microliters to 8.5 microliters; and
moving the plunger and stopper to expel the pegfilgrastim solution into the device.