US 12,343,473 B2
Method and apparatus for treating hyperarousal disorder
Bodiyabaduge Dimithri Joseph Perera, Sydney (AU); Dinesh Ramanan, Telopea (AU); Gordon Joseph Malouf, Sydney (AU); Liam Holley, Sydney (AU); and Neha Banodkar, Sydney (AU)
Assigned to ResMed Pty Ltd, (AU)
Appl. No. 15/733,438
Filed by ResMed Pty Ltd, Bella Vista (AU)
PCT Filed Feb. 15, 2019, PCT No. PCT/AU2019/050123
§ 371(c)(1), (2) Date Jul. 30, 2020,
PCT Pub. No. WO2019/157563, PCT Pub. Date Aug. 22, 2019.
Claims priority of application No. 2018900477 (AU), filed on Feb. 15, 2018.
Prior Publication US 2021/0330910 A1, Oct. 28, 2021
Int. Cl. A61M 16/00 (2006.01); A61B 5/00 (2006.01)
CPC A61M 16/0069 (2014.02) [A61B 5/00 (2013.01); A61M 16/0003 (2014.02); A61M 16/026 (2017.08); A61M 2016/0027 (2013.01); A61M 2016/0036 (2013.01); A61M 2205/3331 (2013.01); A61M 2205/505 (2013.01); A61M 2205/584 (2013.01); A61M 2230/42 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A method of determining settings for control of bi-level respiratory pressure therapy for slowing a patient's breathing, the method comprising:
determining an interim target breathing rate that is less than a current spontaneous breathing rate of the patient;
deriving a target inspiratory time and a target expiratory time, each of the target inspiratory time and the target expiratory time being derived based on the interim target breathing rate;
computing, with one or more first functions, a set of parameters for generating a variable treatment pressure waveform based on the target inspiratory time and the target expiratory time, wherein the set of parameters comprise a plurality of pressure values and a plurality of exponents, wherein the plurality of pressure values represent endpoints of the variable treatment pressure waveform during inspiratory and expiratory phases of the variable treatment pressure waveform, and the plurality of exponents shape a curvature of the variable treatment pressure waveform during the inspiratory and expiratory phases;
determining pressure settings by generating the variable treatment pressure waveform with the computed set of parameters and one or more second functions; and
reducing the interim target breathing rate in response to a subsequent spontaneous breathing rate of the patient slowing down toward the interim target breathing rate; and
controlling a blower to generate the bi-level respiratory pressure therapy according to the determined pressure settings.