US 12,343,453 B2
Degradable regenerative medical material for promoting tissue in-situ regeneration and preparation method therefor
Chuangzhou Guo, Beijing (CN); Fang Hu, Beijing (CN); Yuexiu Qiu, Beijing (CN); and Xiaoli Yu, Beijing (CN)
Assigned to BEIJING BEST LIFE REGENERATIVE MEDICINE TECHNOLOGY CO. LTD, Beijing (CN)
Appl. No. 17/596,627
Filed by BEIJING BEST LIFE REGENERATIVE MEDICINE TECHNOLOGY CO. LTD, Beijing (CN)
PCT Filed Sep. 19, 2019, PCT No. PCT/CN2019/106736
§ 371(c)(1), (2) Date Dec. 15, 2021,
PCT Pub. No. WO2020/252957, PCT Pub. Date Dec. 24, 2020.
Claims priority of application No. 201910538684 (CN), filed on Jun. 20, 2019.
Prior Publication US 2022/0296785 A1, Sep. 22, 2022
Int. Cl. A61L 27/54 (2006.01); A61L 27/02 (2006.01); A61L 27/12 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/54 (2013.01) [A61L 27/025 (2013.01); A61L 27/12 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 2300/412 (2013.01)] 8 Claims
 
1. A method for preparing a degradable regenerative medical material for promoting tissue in-situ regeneration, wherein, the degradable regenerative medical material is formed by means of chemically bonding Si, P, O and metallic elements containing calcium, and is a three-dimensional network structure comprising a mesoporous structure wherein macropores that communicate with each other are uniformly distributed in the three-dimensional network structure, and in terms of mole portions, raw materials for preparing the degradable regenerative medical material include:
40-78 portions of a silicate ester;
1-17 portions of a phosphate ester;
110-200 portions of water;
20-40 portions of a soluble metal salt containing calcium;
0.01-5 portions of a catalyst;
1-5 portions of an alcohol solvent;
0.1-5 portions of a thickener;
1-5 portions of a foam stabilizer;
5-10 portions of a foam fixative; and
1-10 portions of a foaming agent;
characterized by comprising the steps of:
mixing a sol: add the catalyst to the water and stir uniformly, then add the silicate ester and the phosphate ester for pre-hydrolysis reaction, hydrolyze until the mixture solution becomes transparent, then add the soluble metal salt, and stir until completely dissolved to obtain a mixed sol;
foaming and curing: disperse the thickener with the alcohol solvent, and then add to the mixed sol, stir until completely swollen and dissolved, add the foam stabilizer and the foam fixative, stir uniformly, then age, then add the foaming agent and stir uniformly to obtain a mixture material, and then heat the mixture material for foaming and curing, and then dry cured foam to obtain a foam body; and
calcining: calcine the foam body until organics are completely removed, to obtain the degradable regenerative medical material with a three-dimensional network structure for promoting tissue in-situ regeneration,
wherein,
in the step of foaming and curing, the aging is room temperature aging and refers to aging until a viscosity reaches 6000-20000 cp, and then cooling down to below 25° C.; and the speed of the stirring is 120-300 r/min after adding the foaming agent; and
in the step of foaming and curing, the temperature of the heating for foaming and curing is 60-100° C., and the time of the heating for foaming and curing is 0.5-1 h.