US 12,343,452 B2
Fluorosilinated liquid-infused surfaces with embedded biomolecules, methods of making and uses thereof
Tohid F. Didar, Dundas (CA); Maryam Badv, Hamilton (CA); Zachary Cetinic, Toronto (CA); and Amid Shakeri, Hamilton (CA)
Assigned to McMaster University, Hamilton (CA)
Appl. No. 16/960,649
Filed by McMaster University, Hamilton (CA)
PCT Filed Jan. 9, 2019, PCT No. PCT/CA2019/050033
§ 371(c)(1), (2) Date Jul. 8, 2020,
PCT Pub. No. WO2019/136560, PCT Pub. Date Jul. 18, 2019.
Claims priority of provisional application 62/615,205, filed on Jan. 9, 2018.
Prior Publication US 2020/0330649 A1, Oct. 22, 2020
Int. Cl. A61L 27/54 (2006.01); A61K 47/69 (2017.01); A61L 27/28 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); B01J 19/00 (2006.01); C03C 17/30 (2006.01)
CPC A61L 27/54 (2013.01) [A61K 47/6901 (2017.08); A61L 27/28 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); B01J 19/0046 (2013.01); C03C 17/30 (2013.01); A61L 2400/18 (2013.01); A61L 2420/06 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00637 (2013.01); C03C 2218/31 (2013.01); C03C 2218/33 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for producing biofunctional fluorosilinated substrates comprising
a. coating a surface of a substrate with a fluorosilane to create at least one fluorosilane monolayer on the surface to provide a fluorosilinated surface on the substrate wherein the substrate comprises surface hydroxyl groups or has been treated to form surface hydroxyl groups;
b. plasma etching the fluorosilinated surface on the substrate to provide reactive functional groups on at least a portion of the fluorosilinated surface of the substrate; and
c. attaching biospecies to the reactive functional groups to obtain the biofunctional fluorosilinated substrates,
wherein the plasma etching in b is for about 10 seconds to about 1 minute and reduces the atomic percentage of fluorine on the substrate by no more than 10% as determined using xray photoelectron spectroscopy (XPS).