	US 12,343,449 B2
	Osteoconductive fibers, medical implant comprising such osteoconductive fibers, and methods of making
Aylvin Jorge Angelo Athanasius Dias, Echt (NL); Noel L. Davison, Echt (NL); Anne Marie Persson, Echt (NL); Ynze Mengerink, Echt (NL); and Paul Mathieu De Bueger, Echt (NL)
Assigned to DSM IP ASSETS B.V., Heerlen (NL)
Appl. No. 16/976,123
Filed by DSM IP Assets B.V., Heerlen (NL)
PCT Filed Mar. 6, 2019, PCT No. PCT/EP2019/055604 § 371(c)(1), (2) Date Aug. 27, 2020, PCT Pub. No. WO2019/170769, PCT Pub. Date Sep. 12, 2019.
Claims priority of application No. 18160350 (EP), filed on Mar. 6, 2018.
Prior Publication US 2021/0299332 A1, Sep. 30, 2021
Int. Cl. A61L 27/46 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); C08L 23/06 (2006.01); D01F 1/10 (2006.01); D01F 11/06 (2006.01)

CPC A61L 27/46 (2013.01) [A61L 27/54 (2013.01); A61L 27/56 (2013.01); C08L 23/06 (2013.01); D01F 1/10 (2013.01); D01F 11/06 (2013.01); A61L 2400/18 (2013.01); A61L 2430/02 (2013.01); A61L 2430/10 (2013.01); C08L 2207/068 (2013.01)]

19 Claims

1. A high-strength polyolefin composite fiber, which fiber has a fiber body consisting of a composition, optionally a spin finish, and optionally an anti-microbial agent on the surface of the fiber, the composition consisting of:

a) a polyolefin, wherein the polyolefin is ultra-high molecular weight polyethylene (UHMWPE);

b) 1-30 mass % of bioceramic particles having particle size D50 of 0.01-10 μm;

c) at most 0.05 mass % of residual spin solvent;

d) optionally 0-3 mass % of other additives selected from the group consisting of anti-static agents, anti-oxidants, stabilizers, colorants, lubricants, and combinations thereof; and

wherein the sum of a)-d) is 100 mass %;

wherein the fiber body has bioceramic particles exposed at the surface of the fiber body, partly embedded in the surface of the fiber body, and not fully covered by the polyolefin and the bioceramic particles show bioactivity, in addition to bioceramic particles that are fully embedded in the polyolefin and not exposed at the surface of the fiber body, and wherein the fiber has a tensile strength of at least 15 cN/dtex.