	US 12,343,417 B2
	Antiperspirant compositions
Simeon Dobrev Stoyanov, Spijkenisse (NL); Philip Christopher Waterfield, Heswall (GB); and Aneliya Nikolova Zdravkova, Liverpool (GB)
Assigned to Conopco, Inc., Hoboken, NJ (US)
Appl. No. 17/283,748
Filed by Conopco, Inc., Trumbull, CT (US)
PCT Filed Nov. 4, 2019, PCT No. PCT/EP2019/080099 § 371(c)(1), (2) Date Apr. 8, 2021, PCT Pub. No. WO2020/094568, PCT Pub. Date May 14, 2020.
Claims priority of application No. 18204724 (EP), filed on Nov. 6, 2018.
Prior Publication US 2021/0378927 A1, Dec. 9, 2021
Int. Cl. A61K 8/36 (2006.01); A61K 8/06 (2006.01); A61K 8/19 (2006.01); A61K 8/27 (2006.01); A61K 8/73 (2006.01); A61Q 15/00 (2006.01)

CPC A61K 8/361 (2013.01) [A61K 8/062 (2013.01); A61K 8/19 (2013.01); A61K 8/27 (2013.01); A61K 8/731 (2013.01); A61K 8/737 (2013.01); A61Q 15/00 (2013.01); A61K 2800/48 (2013.01); A61K 2800/5422 (2013.01); A61K 2800/5426 (2013.01); A61K 2800/874 (2013.01)]

18 Claims

1. An oil-in-water emulsion comprising:

(i) a C₁₀-C₂₂fatty acid that is a liquid at one atmosphere pressure and 25° C.;

(ii) an emulsifier for the C₁₀-C₂₂fatty acid; and

(iii) a water-soluble metal salt that forms a water-insoluble salt with the C₁₀-C₂₂fatty acid at a pH of greater than 6;

wherein the oil-in-water emulsion does not comprise aluminum salts or zirconium salts;

wherein the water-soluble metal salt is divalent;

wherein a molar ratio of the C₁₀-C₂₂fatty acid to a cation of the water-soluble metal salt divided by a cation of the water-soluble metal salt's valence is from 1:2 to 2:1;

and further wherein the oil-in-water emulsion increases by at least 1 pH unit after application to a skin surface, which results in gelation of the oil-in-water emulsion comprising the water-soluble metal salt and the C₁₀-C₂₂fatty acid.